Lysophospholipid mediators in health and disease
Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-
phosphate (S1P), are produced by the metabolism and perturbation of biological …
phosphate (S1P), are produced by the metabolism and perturbation of biological …
Autotaxin and LPA receptor signaling in cancer
AJS Houben, WH Moolenaar - Cancer and Metastasis Reviews, 2011 - Springer
Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) is a lipid mediator that
functions as a mitogen and motility factor for many cell types. LPA signals through six …
functions as a mitogen and motility factor for many cell types. LPA signals through six …
[PDF][PDF] Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions
Pruritus is a seriously disabling symptom accompanying many cholestatic liver disorders.
Recent experimental evidence implicated the lysophospholipase, autotaxin (ATX), and its …
Recent experimental evidence implicated the lysophospholipase, autotaxin (ATX), and its …
Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
H Nishimasu, S Okudaira, K Hama, E Mihara… - Nature structural & …, 2011 - nature.com
Autotaxin (ATX, also known as Enpp2) is a secreted lysophospholipase D that hydrolyzes
lysophosphatidylcholine to generate lysophosphatidic acid (LPA), a lipid mediator that …
lysophosphatidylcholine to generate lysophosphatidic acid (LPA), a lipid mediator that …
Autotaxin—an LPA producing enzyme with diverse functions
K Nakanaga, K Hama, J Aoki - The journal of biochemistry, 2010 - academic.oup.com
Autotaxin (ATX) is an ecto-enzyme responsible for lysophosphatidic acid (LPA) production in
blood. ATX is present in various biological fluids such as cerebrospinal and seminal fluids …
blood. ATX is present in various biological fluids such as cerebrospinal and seminal fluids …
Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer
Autotaxin (ATX) is a member of the nucleotide pyrophosphatase/phosphodiesterase family
of ectoenzymes that hydrolyzes phosphodiester bonds of various nucleotides. It possesses …
of ectoenzymes that hydrolyzes phosphodiester bonds of various nucleotides. It possesses …
Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice
MGK Benesch, X Tang, T Maeda, A Ohhata… - The FASEB …, 2014 - Wiley Online Library
Autotaxin is a secreted enzyme that produces most extracellular lysophosphatidate, which
stimulates 6 G‐protein‐coupled receptors. Lysophosphatidate promotes cancer cell survival …
stimulates 6 G‐protein‐coupled receptors. Lysophosphatidate promotes cancer cell survival …
New insights into the autotaxin/LPA axis in cancer development and metastasis
R Leblanc, O Peyruchaud - Experimental cell research, 2015 - Elsevier
Lysophosphatidic acid (LPA) is a simple lipid with a single fatty acyl chain linked to a
glycerophosphate backbone. Despite the simplicity of its structure but owing to its …
glycerophosphate backbone. Despite the simplicity of its structure but owing to its …
[HTML][HTML] LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling
Persistent T cell antigen receptor (TCR) signaling by CD8 T cells is a feature of cancer and
chronic infections and results in the sustained expression of, and signaling by, inhibitory …
chronic infections and results in the sustained expression of, and signaling by, inhibitory …
Controlling cancer through the autotaxin–lysophosphatidic acid receptor axis
M Gotoh, Y Fujiwara, J Yue, J Liu… - Biochemical Society …, 2012 - portlandpress.com
LPA (lysophosphatidic acid, 1-acyl-2-hydroxy-sn-glycero-3-phosphate), is a growth factor-
like lipid mediator that regulates many cellular functions, many of which are unique to …
like lipid mediator that regulates many cellular functions, many of which are unique to …