The hypocretins/orexins are two excitatory neuropeptides, alternately called HCRT1 or
orexin-A and HCRT2 or orexin-B, that are the endogenous ligands for two G-protein-coupled …

At the end of the 20th century, two new neuropeptides (Orexin-A/hypocretin-1 and Orexin-
B/hypocretins-2) expressed in hypothalamus as a prepro-orexins precursor, were …

Peptides promote the mitogenesis and migration of tumor cells, and cancer cells
overexpress peptide receptors. The involvement of the orexinergic system in cancer is …

Introduction: The orexin system consists of two G-protein-coupled receptors, orexin 1 and
orexin 2 and two endogenous ligands, orexin A and orexin B. It is evolutionarily highly …

Twenty years have passed since the discovery of the Hypocretins/Orexins [1, 2], as we have
witnessed an amazing set of discoveries demonstrating key roles for these transmitters in …

The main objective of this dissertation was to gain an understanding of orexin receptor
activation at the molecular level and apply it in discovery of novel orexin receptor ligands. As …