Evidence from human and animal studies suggests that high-energy diets impair cognitive
function. However, the conditions for such impairments are unclear as studies have differed …

Obesity is a global pandemic associated with macro-and microvascular endothelial
dysfunction. Microvascular endothelial dysfunction has recently emerged as a significant risk …

First seen as a fat-storage tissue, the adipose tissue is considered as a critical player in the
endocrine system. Precisely, adipose tissue can produce an array of bioactive factors …

Background Metabolic syndrome (MS) is defined as a low-grade proinflammatory state in
which abnormal metabolic and cardiovascular factors increase the risk of developing …

Alzheimer's disease (AD) is a multifactorial condition in which, along with amyloid-(A) and
tau-related pathology, the synergistic activity of co-morbidity factors promote the onset and …

Obesity arising from excessive dietary fat intake is a risk factor for cognitive decline,
dementia and neurodegenerative diseases, including Alzheimer's disease. Here, we studied …

Adolescence represents a crucial period for maturation of brain structures involved in
cognition. Early in life unhealthy dietary patterns are associated with inferior cognitive …

Trillions of microbial oscillators reside throughout the mammalian body, yet their
contributions toward fundamental features of host circadian rhythms (CRs) have not been …

Abstract Background Neurodegenerative diseases (NDDs), including Alzheimer's disease
(AD) and Parkinson's disease (PD), are associated with metabolic abnormalities. Integrative …

The aim of this study was to indentify the involvement of leptin receptors (LepR) in astrocytes
in hippocampal synaptic transmission and plasticity and metabolism. To this end we used a …