Vibrational spectroscopy is an essential tool in chemical analyses, biological assays, and
studies of functional materials. Over the past decade, various coherent nonlinear vibrational …

Conspectus Over the past decade, we have developed a spectroscopic approach to
measure electric fields inside matter with high spatial (< 1 Å) and field (< 1 MV/cm) …

Enzymes use protein architecture to impose specific electrostatic fields onto their bound
substrates, but the magnitude and catalytic effect of these electric fields have proven difficult …

Proteins exhibit structural fluctuations over decades of time scales. From the picosecond
side chain motions to aggregates that form over the course of minutes, characterizing protein …

We review the standard model for de novo computational design of enzymes, which
primarily focuses on the development of an active-site geometry, composed of protein …

Nitriles are widely used vibrational probes; however, the interpretation of their IR
frequencies is complicated by hydrogen bonding (H-bonding) in protic environments. We …

What happens inside an enzyme's active site to allow slow and difficult chemical reactions to
occur so rapidly? This question has occupied biochemists' attention for a long time …

The first step toward understanding most of the chemical and biological processes in
condensed phases is to accurately describe solute− solvent interaction energy and to …

It is well-known that the C⋮ N stretching vibration in acetonitrile is sensitive to solvent.
Therefore, we proposed in this contribution to use this vibrational mode to report local …

Applications of 2D IR Spectroscopy to Peptides, Proteins, and Hydrogen-Bond Dynamics | The
Journal of Physical Chemistry B ACS ACS Publications C&EN CAS Find my institution Log In …