The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently
discovered member of the opioid receptor family and, together with its endogenous ligand …

Opioids are effective analgesics, but their use is beset by serious side effects, including
addiction and respiratory depression, which contribute to the ongoing opioid crisis. The …

This paper is the thirty-fifth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2012 …

Misuse of prescription opioids, opioid addiction, and overdose underscore the urgent need
for developing addiction-free effective medications for treating severe pain. Mu opioid …

In our society today, pain has become a main source of strain on most individuals. It is
crucial to develop novel treatments against pain while focusing on decreasing their adverse …

Despite similar distribution patterns and intracellular events observed in the
nociceptin/orphanin FQ peptide (NOP) receptor and other opioid receptors, NOP receptor …

Although mu opioid (MOP) receptor agonists are the most commonly used analgesics for the
treatment of moderate to severe pain in the clinic, the side effects of MOP agonists such as …

Recently, mixed opioid/NOP agonists came to the spotlight for their favorable functional
profiles and promising outcomes in clinical trials as novel analgesics. This study reports on …

Cannabinoid receptor 2 (CB2), a G protein-coupled receptor (GPCR), is a promising target
for the treatment of neuropathic pain, osteoporosis, immune system, cancer, and drug …

Morphine is the most widely used compound among narcotic analgesics and remains the
gold standard when the effects of other analgetic drugs are compared. The most …