Abstract p53 is an important tumour suppressor gene, with loss of p53 contributing to the
development of most human cancers. However, the activation of p53 in response to stress …

CCDC (coiled-coil domain-containing) is a coiled helix domain that exists in natural proteins.
There are about 180 CCDC family genes, encoding proteins that are involved in intercellular …

The p53 family of tumor suppressors, which includes p53, p63, and p73, has a critical role in
many biological processes, such as cell cycle arrest, apoptosis, and differentiation. In …

Coiled-coil domain containing 3 (CCDC3) was previously shown to regulate liver lipid
metabolism as a secretory protein. Here, we report an unexpected intracellular role of …

The p63 protein has pleiotropic functions and, in the liver, participates in the progression of
nonalcoholic fatty liver disease (NAFLD). However, its functions in hepatic stellate cells …

Background The assessment of obesity-related health risks has traditionally relied on the
Body Mass Index and waist circumference, but their limitations have propelled the need for a …

The use of misidentified and contaminated cell lines continues to be a problem in
biomedical research. Research Resource Identifiers (RRIDs) should reduce the prevalence …

Unraveling the molecular nature of skin aging and keratinocyte senescence represents a
challenging research project in epithelial biology. In this regard, depletion of p63, a p53 …

Coiled-coil domain containing 3 (CCDC3, also called Favine) is a highly conserved protein
initially identified as a protein secreted from adipocytes and endothelial cells in the vascular …

By comparing differentially abundant proteins and metabolites, the protein expression,
metabolic changes and metabolic regulation mechanisms during the priming phase of liver …