The translationally controlled tumour protein (TCTP)

UA Bommer, BJ Thiele - The international journal of biochemistry & cell …, 2004 - Elsevier
The translationally controlled tumour protein (TCTP) is a highly conserved protein that is
widely expressed in all eukaryotic organisms. Based on its sequence, TCTP was listed as a …

STEAP proteins: from structure to applications in cancer therapy

IM Gomes, CJ Maia, CR Santos - Molecular Cancer Research, 2012 - AACR
The human 6-transmembrane epithelial antigen of prostate (STEAP) family comprises
STEAP1, STEAP2, STEAP3, and STEAP4. All of these proteins are unique to mammals and …

High recovery FASP applied to the proteomic analysis of microdissected formalin fixed paraffin embedded cancer tissues retrieves known colon cancer markers

JR Wisniewski, P Ostasiewicz… - Journal of proteome …, 2011 - ACS Publications
Proteomic analysis of samples isolated by laser capture microdissection from clinical
specimens requires sample preparation and fractionation methods suitable for small …

Reciprocal repression between P53 and TCTP

R Amson, S Pece, A Lespagnol, R Vyas, G Mazzarol… - Nature medicine, 2012 - nature.com
Screening for genes that reprogram cancer cells for the tumor reversion switch identified
TCTP (encoding translationally controlled tumor protein) as a crucial regulator of apoptosis …

Biological models and genes of tumor reversion: Cellular reprogramming through tpt1/TCTP and SIAH-1

M Tuynder, L Susini, S Prieur… - Proceedings of the …, 2002 - National Acad Sciences
Tumor reversion is the process by which some cancer cells lose their malignant phenotype.
This study was aimed at defining some of the molecular and phenotypic properties of this …

Heme as trigger and target for trioxane-containing antimalarial drugs

B Meunier, A Robert - Accounts of chemical research, 2010 - ACS Publications
Heme is not only just the binding site responsible for oxygen transport by hemoglobin, but it
is also the prosthetic group of many different heme-containing enzymes, such as …

Stabilization and enhancement of the antiapoptotic activity of mcl-1 by TCTP

H Liu, HW Peng, YS Cheng, HS Yuan… - … and cellular biology, 2005 - Am Soc Microbiol
Abstract Mcl-1 is one Bcl-2 family member that plays a pivotal role in animal development.
The extremely labile nature of the Mcl-1 protein itself and the fact that the Mcl-1 level is a …

TCTP protects from apoptotic cell death by antagonizing bax function

L Susini, S Besse, D Duflaut, A Lespagnol… - Cell Death & …, 2008 - nature.com
Translationally controlled tumor protein (TCTP) is a potential target for cancer therapy. It
functions as a growth regulating protein implicated in the TSC1–TSC2–mTOR pathway or a …

A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue-or cell type–specific manner

SH Chen, PS Wu, CH Chou, YT Yan, H Liu… - Molecular biology of …, 2007 - Am Soc Cell Biol
Translationally controlled Tumor Protein (TCTP) is an evolutionally highly conserved protein
which has been implicated in many cellular functions that are related to cell growth, death …

Recent advances in the understanding of brown spider venoms: From the biology of spiders to the molecular mechanisms of toxins

LH Gremski, D Trevisan-Silva, VP Ferrer… - Toxicon, 2014 - Elsevier
The Loxosceles genus spiders (the brown spiders) are encountered in all the continents,
and the clinical manifestations following spider bites include skin necrosis with gravitational …