Nonenzymatic metabolic reactions and life's origins
Prebiotic chemistry aims to explain how the biochemistry of life as we know it came to be.
Most efforts in this area have focused on provisioning compounds of importance to life by …
Most efforts in this area have focused on provisioning compounds of importance to life by …
Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration
Perturbations in iron homeostasis and iron accumulation feature in several
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …
Prebiotic peptides: Molecular hubs in the origin of life
The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …
Biomimetic mineralization based on self-assembling peptides
Q Li, Y Wang, G Zhang, R Su, W Qi - Chemical Society Reviews, 2023 - pubs.rsc.org
Biomimetic science has attracted great interest in the fields of chemistry, biology, materials
science, and energy. Biomimetic mineralization is the process of synthesizing inorganic …
science, and energy. Biomimetic mineralization is the process of synthesizing inorganic …
Small bioactive peptides for biomaterials design and therapeutics
IW Hamley - Chemical reviews, 2017 - ACS Publications
This review is aimed to provide a concise yet extensive survey of key short bioactive peptide
sequences for a range of applications ranging from biomaterials development to peptides …
sequences for a range of applications ranging from biomaterials development to peptides …
Treatment of Wound Infections in a Mouse Model Using Zn2+-Releasing Phage Bound to Gold Nanorods
H Peng, D Rossetto, SS Mansy, MC Jordan, KP Roos… - ACS …, 2022 - ACS Publications
Infections caused by drug-resistant bacteria, particularly Gram-negative organisms, are
increasingly difficult to treat using antibiotics. A potential alternative is “phage therapy”, in …
increasingly difficult to treat using antibiotics. A potential alternative is “phage therapy”, in …
Prebiotic synthesis of cysteine peptides that catalyze peptide ligation in neutral water
CS Foden, S Islam, C Fernández-García, L Maugeri… - Science, 2020 - science.org
Peptide biosynthesis is performed by ribosomes and several other classes of enzymes, but a
simple chemical synthesis may have created the first peptides at the origins of life. α …
simple chemical synthesis may have created the first peptides at the origins of life. α …
A prebiotic basis for ATP as the universal energy currency
ATP is universally conserved as the principal energy currency in cells, driving metabolism
through phosphorylation and condensation reactions. Such deep conservation suggests that …
through phosphorylation and condensation reactions. Such deep conservation suggests that …
Peptides before and during the nucleotide world: An origins story emphasizing cooperation between proteins and nucleic acids
SD Fried, K Fujishima, M Makarov… - Journal of the …, 2022 - royalsocietypublishing.org
Recent developments in Origins of Life research have focused on substantiating the
narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular …
narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular …
On the origin of superoxide dismutase: an evolutionary perspective of superoxide-mediated redox signaling
AJ Case - Antioxidants, 2017 - mdpi.com
The field of free radical biology originated with the discovery of superoxide dismutase (SOD)
in 1969. Over the last 5 decades, a plethora of research has been performed in species …
in 1969. Over the last 5 decades, a plethora of research has been performed in species …