Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

Abstract Naive CD4+ and CD8+ T cells undergo unique developmental programs after
activation, resulting in the generation of effector and long-lived memory T cells. Recent …

Severe SARS-CoV-2 infections are characterized by lymphopenia, but the mechanisms
involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized …

Abstract Indoleamine 2, 3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that,
expressed by different cell types, has regulatory effects on T cells resulting from tryptophan …

T cells are critical in orchestrating protective immune responses to cancer and an array of
pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting …

Regulated glycosylation controls T cell processes, including activation, differentiation and
homing by creating or masking ligands for endogenous lectins. Here we show that stimuli …

A properly functioning immune system is dependent on programmed cell death at virtually
every stage of lymphocyte development and activity. This review addresses the …

Our understanding of the pathogenesis of atopic dermatitis (AD) and its relationship to
asthma remains incomplete. Herein, we describe a murine model of epicutaneous (EC) …

In degenerative disorders of the central nervous system (CNS), transplantation of neural
multipotent (stem) precursor cells (NPCs) is aimed at replacing damaged neural cells,. Here …

Dendritic cells (DCs) are unique in their ability to stimulate T cells and initiate adaptive
immunity. Injection of mice with the cytokine Flt3-ligand (FL) dramatically expands mature …