Therapeutic strategies targeting connexins

DW Laird, PD Lampe - Nature reviews Drug discovery, 2018 - nature.com
The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …

Gap junctions and the connexin protein family

G Söhl, K Willecke - Cardiovascular research, 2004 - academic.oup.com
Gap junctions (Gj) form conduits between adjacent cells that are composed of connexin (Cx)
protein subunits and allow direct intercellular communication. To date, the connexin gene …

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

J Wahis, A Baudon, F Althammer, D Kerspern… - Nature …, 2021 - nature.com
Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural
circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby …

Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning

L Hösli, N Binini, KD Ferrari, L Thieren, ZJ Looser… - Cell reports, 2022 - cell.com
The mechanisms by which astrocytes modulate neural homeostasis, synaptic plasticity, and
memory are still poorly explored. Astrocytes form large intercellular networks by gap junction …

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

U Pannasch, D Freche, G Dallérac, G Ghézali… - Nature …, 2014 - nature.com
Astrocytes play active roles in brain physiology by dynamic interactions with neurons.
Connexin 30, one of the two main astroglial gap-junction subunits, is thought to be involved …

Astroglial networks scale synaptic activity and plasticity

U Pannasch, L Vargová, J Reingruber… - Proceedings of the …, 2011 - National Acad Sciences
Astrocytes dynamically interact with neurons to regulate synaptic transmission. Although the
gap junction proteins connexin 30 (Cx30) and connexin 43 (Cx43) mediate the extensive …

The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus

A Wallraff, R Köhling, U Heinemann… - Journal of …, 2006 - Soc Neuroscience
Astrocytic gap junctions have been suggested to contribute to spatial buffering of potassium
in the brain. Direct evidence has been difficult to gather because of the lack of astrocyte …

Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential

P Wangemann - The Journal of physiology, 2006 - Wiley Online Library
The exquisite sensitivity of the cochlea, which mediates the transduction of sound waves into
nerve impulses, depends on the endocochlear potential and requires a highly specialized …

An update on connexin genes and their nomenclature in mouse and man

G Söhl, K Willecke - Cell communication & adhesion, 2003 - Taylor & Francis
Gap junctions, composed of connexin protein subunits, allow direct communication through
conduits between neighboring cells. Twenty and twenty-one members of the connexin gene …

Emerging role for astroglial networks in information processing: from synapse to behavior

U Pannasch, N Rouach - Trends in neurosciences, 2013 - cell.com
Astrocytes contribute to neurotransmission through a variety of mechanisms ranging from
synapse isolation to active signaling. Astroglial involvement in neurophysiology has been …