The adaptation of populations to local environments often relies on the selection of optimal
values for polygenic traits. Here, we first summarize the results obtained from different …

Viruses interact with hundreds to thousands of proteins in mammals, yet adaptation against
viruses has only been studied in a few proteins specialized in antiviral defense. Whether …

Neanderthals and modern humans interbred at least twice in the past 100,000 years. While
there is evidence that most introgressed DNA segments from Neanderthals to modern …

The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
emphasized the vulnerability of human populations to novel viral pressures, despite the vast …

Understanding general principles about the origin of species remains one of the
foundational challenges in evolutionary biology. The genomic divergence between groups …

Over the course of the last several million years of evolution, humans probably have been
plagued by hundreds or perhaps thousands of epidemics. Little is known about such ancient …

There has been a large literature in the last two decades affirming adaptive DNA sequence
evolution between species. The main lines of evidence are from (i) the McDonald-Kreitman …

Pleiotropy, the control of multiple phenotypes by a single locus, is expected to slow the rate
of adaptation by increasing the chance that beneficial alleles also have deleterious effects …

The possibility of intrinsic barriers to gene flow is often neglected in empirical research on
local adaptation and speciation with gene flow, for example when interpreting patterns …

Gene coexpression networks are a useful tool for summarizing transcriptomic data and
providing insight into patterns of gene regulation in a variety of species. Though there has …