Cancer and Alzheimer's disease inverse relationship: An age-associated diverging derailment of shared pathways

C Lanni, M Masi, M Racchi, S Govoni - Molecular Psychiatry, 2021 - nature.com
Several epidemiological studies show an inverse association between cancer and
Alzheimer's disease (AD). It is debated whether this association is the consequence of …

[HTML][HTML] microRNA diagnostic panel for Alzheimer's disease and epigenetic trade-off between neurodegeneration and cancer

S Nagaraj, KM Zoltowska, K Laskowska-Kaszub… - Ageing research …, 2019 - Elsevier
Abstract microRNAs (miRNAs) have been extensively studied as potential biomarkers for
Alzheimer's disease (AD). Their profiles have been analyzed in blood, cerebrospinal fluid …

Risk of Parkinson disease after depression: a nationwide population-based study

CC Shen, SJ Tsai, CL Perng, BIT Kuo, AC Yang - Neurology, 2013 - AAN Enterprises
Objective: To evaluate the risk of Parkinson disease (PD) among patients with depression by
using the Taiwan National Health Insurance Research Database (NHIRD). Methods: We …

[HTML][HTML] A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer's Disease, Glioblastoma and Lung cancer

J Sánchez-Valle, H Tejero, K Ibáñez, JL Portero… - Scientific reports, 2017 - nature.com
Epidemiological studies indicate that patients suffering from Alzheimer's disease have a
lower risk of developing lung cancer, and suggest a higher risk of developing glioblastoma …

Association of cancer and Alzheimer's disease risk in a national cohort of veterans

L Frain, D Swanson, K Cho, D Gagnon, KP Lu… - Alzheimer's & …, 2017 - Elsevier
Introduction To examine the risk of Alzheimer's disease (AD) among cancer survivors in a
national database. Methods Retrospective cohort of 3,499,378 mostly male US veterans …

Cancer and dementia: it's complicated

M Ganguli - Alzheimer disease & associated disorders, 2015 - journals.lww.com
The relationship between dementia and cancer is complex. A wealth of observational data
suggest (1) reduced risk of certain cancers in Alzheimer and Parkinson diseases; and (2) …

Transcriptomic and genetic associations between Alzheimer's disease, Parkinson's disease, and cancer

J Fores-Martos, C Boullosa, D Rodrigo-Dominguez… - Cancers, 2021 - mdpi.com
Simple Summary Epidemiological studies have identified a link between neurodegenerative
disorders and a reduced risk of overall cancer. Increases and decreases in the risk of site …

Novel functions of the neurodegenerative-related gene tau in cancer

R Gargini, B Segura-Collar… - Frontiers in aging …, 2019 - frontiersin.org
The analysis of global and comparative genomics between different diseases allows us to
understand the key biological processes that explain the etiology of these pathologies. We …

Cancer and dementia: Two sides of the same coin?

KD van der Willik, SB Schagen… - European journal of …, 2018 - Wiley Online Library
Noncentral nervous system cancer and the brain share an interesting and complex relation,
with an emerging body of evidence showing that cancer patients are at an increased risk of …

Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease

JA Driver, XZ Zhou, KP Lu - Biochimica et Biophysica Acta (BBA)-General …, 2015 - Elsevier
Background Pin1 is an intracellular signaling molecule which plays a critical but opposite
role in the pathogenesis of Alzheimer's disease (AD) and many human cancers. Scope of …