Attention-Deficit Hyperactivity Disorder (ADHD) is a complex and heterogeneous
neurodevelopmental condition for which curative treatments are lacking. Whilst …

Drug development for common complex diseases is in need of new molecular entities and
actionable drug targets. MAP/microtubule affinity-regulating kinase 4 (MARK4) is associated …

Although randomized controlled trials remain the scientific ideal for determining the efficacy
and safety of new treatments, they are sometimes insufficient to address the evidentiary …

Personalized medicines hold promise for many diseases. However, demonstrating the
clinical efficacy and cost effectiveness of these medicines can be difficult. It is essential that …

The field of oncology is currently undergoing a paradigm shift. Advances in the
understanding of tumor biology and in tumor sequencing technology have contributed to the …

This book is an accessible introduction for all health professionals interested in the scientific
basis and practical implications of this complex field of practice. Chapters cover a diverse …

Medicines are digitalized as aspects of their regulation and use are embodied in or draw
from interlinked computerized systems and databases. This paper considers how this …

In the aftermath of the economic crisis that started in 2008, resources have become scarcer
than ever in some countries, also in health care. Priority setting and rationalisation of …

The COVID-19 pandemic provides stark evidence of the importance of medicine on a global
scale. However, revisiting the influenza pandemic of 1918 provided a perspective as we …