Permeation enhancers in transdermal drug delivery: Benefits and limitations

A Kováčik, M Kopečná, K Vávrová - Expert opinion on drug delivery, 2020 - Taylor & Francis
Introduction: Transdermal drug delivery has several clinical benefits over conventional
routes of drug administration. To open the transdermal route for a wider range of drugs …

[HTML][HTML] Novel chemical permeation enhancers for transdermal drug delivery

Y Chen, P Quan, X Liu, M Wang, L Fang - Asian Journal of Pharmaceutical …, 2014 - Elsevier
Transdermal drug delivery has been accepted as a potential non-invasive route of drug
administration, with advantages of prolonged therapeutic action, decreased side effect, easy …

[图书][B] Drug delivery systems

VV Ranade, MA Hollinger, JB Cannon - 2003 - taylorfrancis.com
Drug delivery technologies represent a vast and vital area of Research and Development.
The demand for innovative drug delivery systems continues to grow, and this growth …

Current status of amino acid-based permeation enhancers in transdermal drug delivery

R Pereira, SG Silva, M Pinheiro, S Reis, ML Vale - Membranes, 2021 - mdpi.com
Transdermal drug delivery (TDD) presents many advantages compared to other
conventional routes of drug administration, yet its full potential has not been achieved. The …

Esters of terpene alcohols as highly potent, reversible, and low toxic skin penetration enhancers

M Kopečná, M Macháček, A Nováčková… - Scientific reports, 2019 - nature.com
Skin penetration/permeation enhancers are compounds that improve (trans) dermal drug
delivery. We designed hybrid terpene-amino acid enhancers by conjugating natural …

Transdermal drug delivery systems and their use in obesity treatment

Z Li, X Fang, D Yu - International Journal of Molecular Sciences, 2021 - mdpi.com
Transdermal drug delivery (TDD) has recently emerged as an effective alternative to oral
and injection administration because of its less invasiveness, low rejection rate, and …

Topical delivery of lycopene using microemulsions: enhanced skin penetration and tissue antioxidant activity

LB Lopes, H VanDeWall, HT Li, V Venugopal… - Journal of …, 2010 - Elsevier
Topical delivery of lycopene is a convenient way to supplement cutaneous levels of
antioxidants. In this study, lycopene was incorporated (0.05%, w/w) in two microemulsions …

Microemulsions containing medium-chain glycerides as transdermal delivery systems for hydrophilic and hydrophobic drugs

J Hosmer, R Reed, MVLB Bentley, A Nornoo… - Aaps Pharmscitech, 2009 - Springer
We evaluated the ability of microemulsions containing medium-chain glycerides as
penetration enhancers to increase the transdermal delivery of lipophilic (progesterone) and …

Proline, hydroxyproline, and pyrrolidone carboxylic acid derivatives as highly efficient but reversible transdermal permeation enhancers

M Kopečná, M Macháček, J Roh, K Vávrová - Scientific Reports, 2022 - nature.com
Overcoming the skin barrier properties efficiently, temporarily, and safely for successful
transdermal drug delivery remains a challenge. We synthesized three series of potential skin …

Amino acid derivatives as transdermal permeation enhancers

B Janůšová, B Školová, K Tükörová… - Journal of controlled …, 2013 - Elsevier
Transdermal permeation enhancers are compounds that temporarily decrease skin barrier
properties to promote drug flux. In this study, we investigated enhancers with amino acids …