The NOD-like receptor (NLR) family of proteins is a group of pattern recognition receptors
(PRRs) known to mediate the initial innate immune response to cellular injury and stress …

Recognition of DNA by the cell is an important immunological signature that marks the
initiation of an innate immune response. AIM2 is a cytoplasmic sensor that recognizes …

The detection of intracellular microbial DNA is critical to appropriate innate immune
responses; however, knowledge of how such DNA is sensed is limited. Here we identify …

Innate immunity is the first immunological defence against pathogens. During virus infection
detection of nucleic acids is crucial for the inflammatory response. Here we identify DNA …

The innate immune system recognizes conserved pathogen-associated molecular patterns
and produces inflammatory cytokines that direct downstream immune responses. The …

Advances in innate immunity over the past decade have revealed distinct classes of pattern
recognition receptors (PRRs) that detect pathogens at the cell surface and in intracellular …

The NOD-like receptor (NLR) family members are cytosolic sensors of microbial components
and danger signals. A subset of NLRs control inflammasome assembly that results in …

The interferon inducible protein 16 (IFI16) is a prominent sensor of nuclear pathogenic DNA,
initiating innate immune signaling and suppressing viral transcription. However, little is …

Abstract Absent in melanoma 2 (AIM2) is a cytoplasmic sensor that upon recognizing double-
stranded DNA assembles with apoptosis-associated speck-like protein containing a CARD …

Systemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous
manifestations including severe organ damage and vascular dysfunction leading to …