Therapeutic potential of cannabis: a comprehensive review of current and future applications

ZJ Leinen, R Mohan, LS Premadasa, A Acharya… - Biomedicines, 2023 - mdpi.com
Historically, cannabis has been valued for its pain-relieving, anti-inflammatory, and calming
properties. Ancient civilizations like the Egyptians, Greeks, and Chinese medicines …

Cannabinoid treatments in epilepsy and seizure disorders

O Devinsky, NA Jones, MO Cunningham… - Physiological …, 2024 - journals.physiology.org
Cannabis has been used to treat convulsions and other disorders since ancient times. In the
last few decades, preclinical animal studies and clinical investigations have established the …

Structure–Activity Relationship Study of Cannabidiol-Based Analogs as Negative Allosteric Modulators of the μ-Opioid Receptor

T Bosquez-Berger, JA Gudorf, CP Kuntz… - Journal of Medicinal …, 2023 - ACS Publications
The US faces an unprecedented surge in fatal drug overdoses. Naloxone, the only antidote
for opiate overdose, competes at the mu opioid receptor (μOR) orthosteric site. Naloxone …

Presynaptic nanoscale components of retrograde synaptic signaling

B Barti, B Dudok, K Kenesei, M Zöldi, V Miczán… - Science …, 2024 - science.org
While our understanding of the nanoscale architecture of anterograde synaptic transmission
is rapidly expanding, the qualitative and quantitative molecular principles underlying distinct …

GKLF, a transcriptional activator of Txnip, drives microglia activation in kainic acid-induced murine models of epileptic seizures

Z Zhuo, Y Wang, H Kong, T Fu - International Immunopharmacology, 2023 - Elsevier
Neuroinflammation is a major component of epilepsy. Gut-enriched Kruppel-like factor
(GKLF), a transcription factor of Kruppel-like factor family, has been reported to promote …

Restoring prefrontal cortical excitation-inhibition balance with cannabidiol ameliorates neurobehavioral abnormalities in a mouse model of neurodevelopmental …

L Zhang, C Lin, J Zhu, Y He, M Zhan, X Xia, N Yang… - …, 2023 - Elsevier
Maternal immune activation (MIA) resulting from viral infections during pregnancy is linked to
increased rates of neurodevelopmental disorders in offspring. However, the mechanisms …

The development of cannabinoids as therapeutic agents in the United States

CH Murray, BM Gannon, PJ Winsauer, ZD Cooper… - Pharmacological …, 2024 - ASPET
Cannabis is one of the oldest and widely used substances in the world. Cannabinoids within
the cannabis plant, known as phytocannabinoids, mediate cannabis9 effects through …

Adaptive deep spiking neural network with global-local learning via balanced excitatory and inhibitory mechanism

T Jiang, Q Xu, X Ran, J Shen, P Lv… - The Twelfth …, 2023 - openreview.net
The training method of Spiking Neural Networks (SNNs) is an essential problem, and how to
integrate local and global learning is a worthy research interest. However, the current …

[HTML][HTML] Ameliorative effect of Nyctanthes arbor-tristis L. by suppression of pentylenetetrazole-induced kindling in mice: An insight from EEG, neurobehavioral and in …

U Javaid, S Afroz, W Ashraf, KA Saghir… - Biomedicine & …, 2024 - Elsevier
Epilepsy is an abiding condition associated with recurrent seizure attacks along with
associated neurological and psychological emanation owing to disparity of excitatory and …

Activation of GPR55 Ameliorates Maternal Separation-Induced Learning and Memory Deficits by Augmenting 5-HT Synthesis in the Dorsal Raphe Nucleus of Juvenile …

T Sun, YY Du, YQ Zhang, QQ Tian, X Li, JY Yu… - ACS …, 2024 - ACS Publications
Maternal separation (MS) represents a profound early life stressor with enduring impacts on
neuronal development and adult cognitive function in both humans and rodents. MS is …