Gut microbiota in colorectal cancer development and therapy

CC Wong, J Yu - Nature Reviews Clinical Oncology, 2023 - nature.com
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

Cancer pharmacomicrobiomics: targeting microbiota to optimise cancer therapy outcomes

NLN Ting, HCH Lau, J Yu - Gut, 2022 - gut.bmj.com
Despite the promising advances in novel cancer therapy such as immune checkpoint
inhibitors (ICIs), limitations including therapeutic resistance and toxicity remain. In recent …

Current understanding of the intratumoral microbiome in various tumors

C Xue, Q Chu, Q Zheng, X Yuan, Y Su, Z Bao, J Lu… - Cell Reports …, 2023 - cell.com
It is estimated that in the future, the number of new cancer cases worldwide will exceed the
19.3 million recorded in 2020, and the number of deaths will exceed 10 million. Cancer …

The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?

J Ma, L Huang, D Hu, S Zeng, Y Han… - Journal of Experimental & …, 2021 - Springer
The efficacy of cancer immunotherapy largely depends on the tumor microenvironment,
especially the tumor immune microenvironment. Emerging studies have claimed that …

Microbiota in tumors: from understanding to application

Y Xie, F Xie, X Zhou, L Zhang, B Yang… - Advanced …, 2022 - Wiley Online Library
Microbes with complex functions have been found to be a potential component in tumor
microenvironments. Due to their low biomass and other obstacles, intratumor microbiota is …

Role of the gut microbiota and its metabolites in tumorigenesis or development of colorectal cancer

R Qu, Y Zhang, Y Ma, X Zhou, L Sun, C Jiang… - Advanced …, 2023 - Wiley Online Library
Colorectal cancer (CRC) is the most common cancer of the digestive system with high
mortality and morbidity rates. Gut microbiota is found in the intestines, especially the …

Colorectal cancer and gut microbiota studies in China

Z Wang, W Dan, N Zhang, J Fang, Y Yang - Gut Microbes, 2023 - Taylor & Francis
Colorectal cancer (CRC) is the third most common malignant tumor worldwide. The
incidence and mortality rates of CRC have been increasing in China, possibly due to …

Fusobacterium nucleatum Acts as a Pro-carcinogenic Bacterium in Colorectal Cancer: From Association to Causality

S Wang, Y Liu, J Li, L Zhao, W Yan, B Lin… - Frontiers in Cell and …, 2021 - frontiersin.org
Colorectal cancer (CRC) is a common cancer worldwide with complex etiology.
Fusobacterium nucleatum (F. nucleatum), an oral symbiotic bacterium, has been linked with …

Intestinal bacteria and colorectal cancer: etiology and treatment

MW Dougherty, C Jobin - Gut Microbes, 2023 - Taylor & Francis
The etiology of colorectal cancer (CRC) is influenced by bacterial communities that colonize
the gastrointestinal tract. These microorganisms derive essential nutrients from indigestible …

Cancer as microenvironmental, systemic and environmental diseases: opportunity for transdisciplinary microbiomics science

K Inamura, T Hamada, S Bullman, T Ugai, S Yachida… - Gut, 2022 - gut.bmj.com
Cancer is generally regarded as a localised disease, with the well-established role of the
tumour microenvironment. However, the realm of cancer goes beyond the tumour …