Golgi metal ion homeostasis in human health and diseases

J Li, Y Wang - Cells, 2022 - mdpi.com
The Golgi apparatus is a membrane organelle located in the center of the protein processing
and trafficking pathway. It consists of sub-compartments with distinct biochemical …

Sec61 complex/translocon: The role of an atypical ER Ca2+-leak channel in health and disease

JB Parys, F Van Coppenolle - Frontiers in Physiology, 2022 - frontiersin.org
The heterotrimeric Sec61 protein complex forms the functional core of the so-called
translocon that forms an aqueous channel in the endoplasmic reticulum (ER). The primary …

The role of metal ions in the Golgi apparatus

J Gao, A Gao, H Zhou, L Chen - Cell Biology International, 2022 - Wiley Online Library
The Golgi apparatus is a membrane‐bound organelle that functions as a central role in the
secretory pathway. Since the discovery of the Golgi apparatus, its structure and function …

Does lysosomal rupture evoke Ca2+ release? A question of pores and stores

AJ Morgan, Y Yuan, S Patel, A Galione - Cell Calcium, 2020 - Elsevier
Lysosomotropic agents have been used to permeabilize lysosomes and thereby implicate
these organelles in diverse cellular processes. Since lysosomes are Ca 2+ stores, this …

PKC-Mediated Orai1 Channel Phosphorylation Modulates Ca2+ Signaling in HeLa Cells

E Martínez-Martínez, VH Sánchez-Vázquez… - Cells, 2022 - mdpi.com
The overexpression of the Orai1 channel inhibits SOCE when using the Ca2+ readdition
protocol. However, we found that HeLa cells overexpressing the Orai1 channel displayed …

Loss of chloride channel 6 (CLC-6) affects vascular smooth muscle contractility and arterial stiffness via alterations to Golgi calcium stores

CA Klemens, EG Chulkov, J Wu, MA Hye Khan… - …, 2021 - Am Heart Assoc
Genome-wide association studies have found a number of potential genes involved in blood
pressure regulation; however, the functional role of many of these candidates has yet to be …

Heterogeneity of the endoplasmic reticulum Ca2+ store determines colocalization with mitochondria

VH Sánchez-Vázquez, E Martínez-Martínez… - Cell Calcium, 2023 - Elsevier
Contact sites between the endoplasmic reticulum (ER) and mitochondria play a pivotal role
in cell signaling, and the interaction between these organelles is dynamic and finely …

Blockade of CaV3 calcium channels and induction of G0/G1 cell cycle arrest in colon cancer cells by gossypol

O Lopez‐Charcas, O Benouna… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Gastrointestinal tumours overexpress voltage‐gated
calcium (CaV3) channels (CaV3. 1, 3.2 and 3.3). CaV3 channels regulate cell growth and …

Sarco-endoplasmic reticulum calcium release model based on changes in the luminal calcium content

A Guerrero-Hernández, VH Sánchez-Vázquez… - Calcium Signaling, 2020 - Springer
The sarcoplasmic/endoplasmic reticulum (SR/ER) is the main intracellular calcium (Ca 2+)
pool in muscle and non-muscle eukaryotic cells, respectively. The reticulum accumulates Ca …

The Golgi Ca2+ stores, and original contributions by Prof. Shao Bai Xue

ZJ Cui - Biophysics Reports, 2023 - biophysics-reports.org
The Golgi apparatus serves as a distinct part of intracellular Ca 2+ stores. Here, the early
discovery by Professor Shao Bai Xue is reviewed, and the recent progress in the field is …