In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal
viral infection. IFNs are secreted cytokines that activate a signal transduction cascade …

Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …

Metabolism is a major regulator of immune cell function, but it remains difficult to study the
metabolic status of individual cells. Here, we present Compass, an algorithm to characterize …

Viruses manipulate cellular metabolism and macromolecule recycling processes like
autophagy. Dysregulated metabolism might lead to excessive inflammatory and …

Several compounds extracted from spices and herbs exhibit antiviral effects in vitro,
suggesting potential pharmacological uses. Curcumin, a component of turmeric, has been …

Deciphering the cell-state transitions underlying immune adaptation across time is
fundamental for advancing biology. Empirical in vivo genomic technologies that capture …

Beginning in 2004, chikungunya virus (CHIKV) went from an endemic pathogen limited to
Africa and Asia that caused periodic outbreaks to a global pathogen. Given that outbreaks …

Understanding the pathogenesis of SARS-CoV-2 is essential for developing effective
treatment strategies. Viruses hijack the host metabolism to redirect the resources for their …

Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis. This
process is also involved in the antiviral response at multiple levels, including the direct …

Interferons (IFNs) are potent pleiotropic cytokines that broadly alter cellular functions in
response to viral and other infections. These alterations include changes in protein …