Cells interact with their environment, communicate among themselves, track time and make
decisions through functions controlled by natural regulatory genetic circuits consisting of …

As synthetic biology permeates society, the signal processing circuits in engineered living
systems must be customized to meet practical demands. Towards this mission, novel …

The recent devastating pandemic has drastically reminded humanity of the importance of
constant scientific and technological progress. A strong interdisciplinary dialogue between …

The design of modular protein logic for regulating protein function at the posttranscriptional
level is a challenge for synthetic biology. Here, we describe the design of two-input AND …

Cells can be programmed to monitor and react to their environment using genetic circuits.
Design automation software maps a desired circuit function to a DNA sequence, a process …

自然科学各学科的研究对象在时空尺度上的差别与相连, 既决定了学科间的差别,
也决定了学科间的交叉. 生物学在发展到以机理研究为主的“生命科学” 阶段后 …

In multicellular organisms, gene regulatory circuits generate thousands of molecularly
distinct, mitotically heritable states through the property of multistability. Designing synthetic …

The ability to externally control gene expression has been paradigm shifting for all areas of
biological research, especially for synthetic biology. Such control typically occurs at the …

Bacteria exist as communities in diverse multispecies environments. Quorum sensing, a
process for cell–cell communication, allows individual bacteria to glean information about …

Efforts to construct synthetic biological circuits with more complex functions have often been
hindered by the idiosyncratic behavior, limited dynamic range and crosstalk of commonly …