The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
J Yuan, X Dong, J Yap, J Hu - Journal of hematology & oncology, 2020 - Springer
Cancer is characterized as a complex disease caused by coordinated alterations of multiple
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies
ME Bahar, HJ Kim, DR Kim - Signal transduction and targeted therapy, 2023 - nature.com
Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …
underscores the urgent need for enhanced insights into the molecular and cellular …
Targeting aberrant RAS/RAF/MEK/ERK signaling for cancer therapy
U Degirmenci, M Wang, J Hu - Cells, 2020 - mdpi.com
The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter-and intra-
cellular communication, which regulates fundamental cell functions such as growth, survival …
cellular communication, which regulates fundamental cell functions such as growth, survival …
RAF-MEK-ERK pathway in cancer evolution and treatment
Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
The role of PI3K/Akt and ERK in neurodegenerative disorders
SN Rai, H Dilnashin, H Birla, SS Singh, W Zahra… - Neurotoxicity …, 2019 - Springer
Abstract Disruption of Akt and Erk-mediated signal transduction significantly contributes in
the pathogenesis of various neurodegenerative diseases (NDs), such as Parkinson's …
the pathogenesis of various neurodegenerative diseases (NDs), such as Parkinson's …
Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations
Abstract The RAS–RAF–MEK–ERK signaling cascade is among the most frequently mutated
pathways in human cancer. Approximately 50% of melanoma patients possess a druggable …
pathways in human cancer. Approximately 50% of melanoma patients possess a druggable …
Regulation of RAF protein kinases in ERK signalling
H Lavoie, M Therrien - Nature reviews Molecular cell biology, 2015 - nature.com
RAF family kinases were among the first oncoproteins to be described more than 30 years
ago. They primarily act as signalling relays downstream of RAS, and their close ties to …
ago. They primarily act as signalling relays downstream of RAS, and their close ties to …
Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond
M Holderfield, MM Deuker, F McCormick… - Nature Reviews …, 2014 - nature.com
The identification of mutationally activated BRAF in many cancers altered our conception of
the part played by the RAF family of protein kinases in oncogenesis. In this Review, we …
the part played by the RAF family of protein kinases in oncogenesis. In this Review, we …
The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer
This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …
level. First, the interactions between curcumin and its molecular targets are addressed on …
Tumor adaptation and resistance to RAF inhibitors
RAF kinase inhibitors have substantial therapeutic effects in patients with BRAF-mutant
melanoma. However, only rarely do tumors regress completely, and the therapeutic effects …
melanoma. However, only rarely do tumors regress completely, and the therapeutic effects …