How are individual cell behaviors coordinated toward invariant large-scale anatomical
outcomes in development and regeneration despite unpredictable perturbations …

Damage to organs by trauma, infection, diseases, congenital defects, aging, and other
injuries causes organ malfunction and is life-threatening under serious conditions. Some of …

Background Acquired resistance of 5-fluorouracil (5-FU) remains a clinical challenge in
colorectal cancer (CRC), and efforts to develop targeted agents to reduce resistance have …

Unlike mammals, Xenopus laevis tadpoles have a high regenerative potential. To
characterize this regenerative response, we performed single-cell RNA sequencing after tail …

In wound healing, individual cells' behaviors coordinate movement toward the wound center
to restore small or large barrier defects. The migration of epithelial cells as a continuous …

A fundamental step in regeneration is rapid growth to replace lost tissue. Cells must
generate sufficient lipids, nucleotides, and proteins to fuel rapid cell division. To define …

Redox reactions are of high fundamental and practical interest since they are involved in
both normal physiology and the pathogenesis of various diseases. However, this area of …

A major frontier in the post-genomic era is the investigation of the control of coordinated
growth and three-dimensional form. Dynamic remodeling of complex organs in regulative …

The ability to regrow lost or damaged tissues is widespread, but highly variable among
animals. Understanding this variation remains a challenge in regeneration biology …

Highlights•Growth, form and function of complex organs rely on dynamic morphogenesis.•
Morphoceuticals manipulate anatomical decision making by cellular collectives.• …