Since the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a
significant amount of research conducted to explore its regulatory role in the physiology and …

The cardiovascular system provides blood supply throughout the body and as such is
perpetually applying mechanical forces to cells and tissues. Thus, this system is primed with …

Osteoarthritis is a chronic disease that can be initiated by altered joint loading or injury of the
cartilage. The mechanically sensitive PIEZO ion channels have been shown to transduce …

Two prominent concepts for the sensing of shear stress by endothelium are the PIEZO1
channel as a mediator of mechanically activated calcium ion entry and the PECAM1 cell …

Mechanosensitive PIEZO channels constitute potential pharmacological targets for multiple
clinical conditions, spurring the search for potent chemical PIEZO modulators. Among them …

Mechanical force is an essential physical element that contributes to the formation and
function of life. The discovery of the evolutionarily conserved PIEZO family, including PIEZO1 …

Mechanical forces are thought to activate mechanosensitive PIEZO channels by changing
the conformation of a large transmembrane blade domain. Yet, whether different stimuli …

Piezo1, a mechano-activated ion channel, has wide-ranging physiological and therapeutic
implications, with the ongoing development of specific agonists unveiling cellular responses …

Abstract Background & Aims PIEZO1 and TRPV4 are mechanically and osmotically
regulated calcium‐permeable channels. The aim of this study was to determine the …

PIEZO1 channels are mechanically activated cation channels that play a pivotal role in
sensing mechanical forces in various cell types. Their dysfunction has been associated with …