Fungal pathogens pose an increasing threat to public health. Limited clinical drug regimens
and emerging drug-resistant isolates challenge infection control. The global burden of …

The effects of aging on the brain are widespread and can have dramatic implications on the
overall health of an organism. Mitochondrial dysfunction is a hallmark of brain aging, but the …

The present manuscript is an overview of various effects of mTOR up-regulation in
astrocytoma with an emphasis on its deleterious effects on the proliferation of Glioblastoma …

Caspases are best characterized for their function in apoptosis. However, they also have
non-apoptotic functions such as apoptosis-induced proliferation (AiP), where caspases …

Macroautophagy (autophagy) targets cytoplasmic cargoes to the lysosome for degradation.
Like all vesicle trafficking, autophagy relies on phosphoinositide identity, concentration, and …

Apoptosis is an evolutionary conserved cell death mechanism, which requires activation of
initiator and effector caspases. The Drosophila initiator caspase Dronc, the ortholog of …

Apoptosis is regulated cell death that depends on caspases. A specific initiator caspase is
involved upstream of each apoptotic signaling pathway. Characterized in nematode, fly, and …

Background ATG1 belongs to the Uncoordinated-51-like kinase protein family. Members of
this family are best characterized for roles in macroautophagy and neuronal development …

The actin cytoskeleton is a key determinant of cell and tissue homeostasis. However, tissue-
specific roles for actin dynamics in aging, notably brain aging, are not understood. Here, we …

The 2 main degradative pathways that contribute to proteostasis are the ubiquitin-
proteasome system and autophagy but how they are molecularly coordinated is not well …