Snake venoms often contain toxins that cause a rapid necrosis of skeletal muscle fibers,
referred to as myotoxins. The most common among them are phospholipases A2 (PLA2s) …

Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

Envenomation via snakebites is an important public health problem in many tropical and
subtropical countries that, in addition to mortality, can result in permanent sequelae as a …

Abstract Phospholipases A2 (PLA2s) are abundant components in snake venoms, which
play important toxic roles. This review focuses on group II PLA2s endowed with myotoxic …

Two subtypes of phospholipases A2 (PLA2s) with the ability to induce myonecrosis,'Asp49'
and 'Lys49'myotoxins, often coexist in viperid snake venoms. Since the latter lack catalytic …

Myotoxins play a major role in the pathogenesis of the envenomations caused by snake
bites in large parts of the world where this is a very relevant public health problem. We show …

Varespladib (LY315920) is a potent inhibitor of human group IIA phospholipase A 2 (PLA 2)
originally developed to control inflammatory cascades of diseases associated with high or …

Snakebite envenoming is an important public health problem in many tropical and
subtropical countries, and is considered a neglected tropical disease by the World Health …

Viperid venoms often contain mixtures of Asp49 and Lys49 PLA 2 myotoxin isoforms,
relevant to development of myonecrosis. Given their difference in catalytic activity …

Phospholipases A2 are important components of snake venoms, the basic isoforms have
been more extensively studied than the acidic groups, maybe due to their higher toxicity …