The role of pontin and reptin in cellular physiology and cancer etiology
YQ Mao, WA Houry - Frontiers in molecular biosciences, 2017 - frontiersin.org
Pontin (RUVBL1, TIP49, TIP49a, Rvb1) and Reptin (RUVBL2, TIP48, TIP49b, Rvb2) are
highly conserved ATPases of the AAA+ (ATPases Associated with various cellular Activities) …
highly conserved ATPases of the AAA+ (ATPases Associated with various cellular Activities) …
AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy
Autophagy is a highly conserved self-digestion process, which is essential for maintaining
homeostasis and viability in response to nutrient starvation,,,. Although the components of …
homeostasis and viability in response to nutrient starvation,,,. Although the components of …
Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression
Background Oct4, a key stemness transcription factor, is overexpressed in lung cancer.
Here, we reveal a novel transcription regulation of long non-coding RNAs (lncRNAs) by …
Here, we reveal a novel transcription regulation of long non-coding RNAs (lncRNAs) by …
Brd4 and P300 confer transcriptional competency during zygotic genome activation
The awakening of the genome after fertilization is a cornerstone of animal development.
However, the mechanisms that activate the silent genome after fertilization are poorly …
However, the mechanisms that activate the silent genome after fertilization are poorly …
Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy
Autophagy is a catabolic process through which cytoplasmic components are degraded and
recycled in response to various stresses including starvation. Recently, transcriptional and …
recycled in response to various stresses including starvation. Recently, transcriptional and …
Regulation of autophagy by protein methylation and acetylation in cancer
M Jeon, J Park, E Yang, H Baek… - Journal of Cellular …, 2022 - Wiley Online Library
Autophagy is a highly conserved mechanism responsible for cellular homeostasis and
integrity in a variety of physiological conditions. Materials targeted for degradation are …
integrity in a variety of physiological conditions. Materials targeted for degradation are …
Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells
Pluripotency transcription programs by core transcription factors (CTFs) might be reset
during M/G1 transition to maintain the pluripotency of embryonic stem cells (ESCs) …
during M/G1 transition to maintain the pluripotency of embryonic stem cells (ESCs) …
Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice
Autism spectrum disorders (ASDs) are a group of developmental disorders that cause
variable and heterogeneous phenotypes across three behavioral domains such as atypical …
variable and heterogeneous phenotypes across three behavioral domains such as atypical …
Astaxanthin reduces stemness markers in BT20 and T47D breast cancer stem cells by inhibiting expression of pontin and mutant p53
YT Ahn, MS Kim, YS Kim, WG An - Marine drugs, 2020 - mdpi.com
Astaxanthin (AST) is a product made from marine organisms that has been used as an anti-
cancer supplement. It reduces pontin expression and induces apoptosis in SKBR3, a breast …
cancer supplement. It reduces pontin expression and induces apoptosis in SKBR3, a breast …
A novel interaction of ecdysoneless (ECD) protein with R2TP complex component RUVBL1 is required for the functional role of ECD in cell cycle progression
Ecdysoneless (ECD) is an evolutionarily conserved protein whose germ line deletion is
embryonic lethal. Deletion of Ecd in cells causes cell cycle arrest, which is rescued by …
embryonic lethal. Deletion of Ecd in cells causes cell cycle arrest, which is rescued by …