Several epidemiological observations have shown an inverse relation between
consumption of plant-based foods, rich in phytochemicals, and incidence of cancer …

Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

Carotenoids are natural fat-soluble pigments that provide bright coloration to plants and
animals. Dietary intake of carotenoids is inversely associated with the risk of a variety of …

This review is the introduction to a special issue concerning, glutathione (GSH), the most
abundant low molecular weight thiol compound synthesized in cells. GSH plays critical roles …

Occupational or environmental exposures to heavy metals produce several adverse health
effects. The common mechanism determining their toxicity and carcinogenicity is the …

Chemoprevention refers to the use of agents to inhibit, reverse or retard tumorigenesis.
Numerous phytochemicals derived from edible plants have been reported to interfere with a …

A common feature of diverse chemopreventive agents is the ability to activate expression of
a genetic program that protects cells from reactive chemical species that, if left unchecked …

Polyphenols are wide variety of compounds that occur in fruits and vegetables, wine, tea,
extra virgin olive oil, chocolate and other cocoa products. Several polyphenols have been …

Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and
detoxification of xenobiotics and drugs introduced into the human body. Most of the tissues …

Antioxidant response element (ARE)-mediated expression and coordinated induction of
antioxidant enzymes is a critical mechanism of protection against chemically induced …