Evolutionary dynamics of natural product biosynthesis in bacteria
MG Chevrette, K Gutiérrez-García… - Natural product …, 2020 - pubs.rsc.org
Covering: 2008 up to 2019 The forces of biochemical adaptive evolution operate at the level
of genes, manifesting in complex phenotypes and the global biodiversity of proteins and …
of genes, manifesting in complex phenotypes and the global biodiversity of proteins and …
Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases
Covering: up to fall 2022. Nonribosomal peptide synthetases (NRPSs) are a family of
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …
Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility
INTRODUCTION Nonribosomal peptide synthetases (NRPSs) are microbial megaenzymes
that make a wide variety of small-molecule products, including many that are clinically used …
that make a wide variety of small-molecule products, including many that are clinically used …
The many faces and important roles of protein–protein interactions during non-ribosomal peptide synthesis
Covering: up to July 2018 Non-ribosomal peptide synthetase (NRPS) machineries are
complex, multi-domain proteins that are responsible for the biosynthesis of many important …
complex, multi-domain proteins that are responsible for the biosynthesis of many important …
Structures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module
CM Fortinez, K Bloudoff, C Harrigan, I Sharon… - Nature …, 2022 - nature.com
Nonribosomal peptide synthetases (NRPSs) are large modular enzymes that synthesize
secondary metabolites and natural product therapeutics. Most NRPS biosynthetic pathways …
secondary metabolites and natural product therapeutics. Most NRPS biosynthetic pathways …
Nonribosomal peptide synthesis definitely working out of the rules
M Duban, S Cociancich, V Leclère - Microorganisms, 2022 - mdpi.com
Nonribosomal peptides are microbial secondary metabolites exhibiting a tremendous
structural diversity and a broad range of biological activities useful in the medical and agro …
structural diversity and a broad range of biological activities useful in the medical and agro …
Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain
J Wang, D Li, L Chen, W Cao, L Kong, W Zhang… - Nature …, 2022 - nature.com
Nonribosomal peptide synthetases (NRPSs) are modular assembly-line megaenzymes that
synthesize diverse metabolites with wide-ranging biological activities. The structural …
synthesize diverse metabolites with wide-ranging biological activities. The structural …
A proof-reading mechanism for non-proteinogenic amino acid incorporation into glycopeptide antibiotics
M Kaniusaite, J Tailhades, EA Marschall… - Chemical …, 2019 - pubs.rsc.org
Non-ribosomal peptide biosynthesis produces highly diverse natural products through a
complex cascade of enzymatic reactions that together function with high selectivity to …
complex cascade of enzymatic reactions that together function with high selectivity to …
[PDF][PDF] Nonribosomal peptide synthetases and their biotechnological potential in Penicillium rubens
R Iacovelli, RAL Bovenberg… - Journal of Industrial …, 2021 - academic.oup.com
Nonribosomal peptide synthetases (NRPS) are large multimodular enzymes that synthesize
a diverse variety of peptides. Many of these are currently used as pharmaceuticals, thanks to …
a diverse variety of peptides. Many of these are currently used as pharmaceuticals, thanks to …
Structural basis of the nonribosomal codes for nonproteinogenic amino acid selective adenylation enzymes in the biosynthesis of natural products
Nonproteinogenic amino acids are the unique building blocks of nonribosomal peptides
(NRPs) and hybrid nonribosomal peptide–polyketides (NRP–PKs) and contribute to their …
(NRPs) and hybrid nonribosomal peptide–polyketides (NRP–PKs) and contribute to their …