Piper species are aromatic plants used as spices in the kitchen, but their secondary
metabolites have also shown biological effects on human health. These plants are rich in …

Autophagy is a lysosomal degradation process and protective housekeeping mechanism to
eliminate damaged organelles, long-lived misfolded proteins and invading pathogens …

Age is the main risk factor for the prevalent diseases of developed countries: cancer,
cardiovascular disease and neurodegeneration. The ageing process is deleterious for …

Great progress has been made toward understanding the pathogenesis of Parkinson's
disease (PD) during the past two decades, mainly as a consequence of the discovery of …

Background: Our previous study demonstrated that metabolic inflammation exacerbates
dopaminergic neuronal degeneration in type 2 diabetes mice. Metformin, a typical oral …

Sites of close contact between mitochondria and the endoplasmic reticulum (ER) are known
as mitochondria-associated membranes (MAM) or mitochondria-ER contacts (MERCs), and …

The role of phagocytosis in the neuroprotective function of microglia has been appreciated
for a long time, but only more recently a dysregulation of this process has been recognized …

Parkinson's disease (PD) is the second most common cause of neurodegeneration. Over the
last two decades, various hypotheses have been proposed to explain the etiology of PD …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder caused by
selective motor neuron degeneration. Abnormal protein aggregation and impaired protein …

Autophagy is an evolutionarily conserved process that plays a crucial role in maintaining a
series of cellular functions. It has been found that autophagy is closely involved in the …