Neuroinflammation in primary open-angle glaucoma

S Vernazza, S Tirendi, AM Bassi, CE Traverso… - Journal of clinical …, 2020 - mdpi.com
Primary open-angle glaucoma (POAG) is the second leading cause of irreversible blindness
worldwide. Increasing evidence suggests oxidative damage and immune response defects …

How many aqueous humor outflow pathways are there?

C Costagliola, R Dell'Omo, L Agnifili, S Bartollino… - Survey of …, 2020 - Elsevier
The aqueous humor (AH) outflow pathways definition is still matter of intense debate. To
date, the differentiation between conventional (trabecular meshwork) and unconventional …

The effects of graded intraocular pressure challenge on the optic nerve head

N Patel, F McAllister, L Pardon, R Harwerth - Experimental eye research, 2018 - Elsevier
Intraocular pressure (IOP) is an important risk factor for glaucoma, and the response of the
ONH and surrounding tissues to elevated IOP are often investigated to better understand …

A neuroglia-based interpretation of glaucomatous neuroretinal rim thinning in the optic nerve head

EJ Lee, JC Han, C Kee - Progress in Retinal and Eye Research, 2020 - Elsevier
Neuroretinal rim thinning (NRR) is a characteristic glaucomatous optic disc change.
However, the precise mechanism of the rim thinning has not been completely elucidated …

Changes of neuroretinal rim and retinal nerve fiber layer thickness assessed by optical coherence tomography after filtration surgery in glaucomatous eyes

SF Koenig, CW Hirneiss - Clinical Ophthalmology, 2021 - Taylor & Francis
Purpose Lowering the intraocular pressure (IOP) in patients with primary open-angle
glaucoma (POAG) with filtration surgery can induce morphological changes to the bulbus …

Histologic validation of optical coherence tomography-based three-dimensional morphometric measurements of the human optic nerve head: methodology and …

MA Fazio, SK Gardiner, L Bruno, M Hubbard… - Experimental eye …, 2021 - Elsevier
Purpose To compare the three-dimensional (3D) morphology of the deep load-bearing
structures of the human optic nerve head (ONH) as revealed in vivo by spectral domain …

Elevated intraocular pressure causes cellular and molecular retinal injuries, advocating a more moderate intraocular pressure setting during phacoemulsification …

Z Zhao, X Yu, X Yang, J Zhang, D Zhang, N Sun… - International …, 2020 - Springer
Purpose To evaluate the cellular and molecular retinal injuries induced by various
intraocular pressure (IOP) settings in a mouse model of acute ocular hypertension (AOH) …

Effect of trabeculectomy on OCT measurements of the optic nerve head neuroretinal rim tissue

FG Sanchez, DS Sanders, JJ Moon, SK Gardiner… - Ophthalmology …, 2020 - Elsevier
Purpose Ophthalmologists commonly perform glaucoma surgery to treat progressive
glaucoma. Few studies have examined the stability of OCT neuroretinal rim parameters after …

Comparison of retinal nerve fiber layer thickness and Bruch's membrane opening minimum rim width thinning rate in open-angle glaucoma

D Park, SP Park, KI Na - Scientific Reports, 2022 - nature.com
This study aimed to compare the rate of thinning between retinal nerve fiber layer thickness
(RNFLT) and Bruch's membrane opening minimum rim width (BMO-MRW) in open-angle …

Neuroretinal rim response to transient changes in intraocular pressure in healthy non-human primate eyes

LP Pardon, RS Harwerth, NB Patel - Experimental eye research, 2020 - Elsevier
Optic nerve head (ONH) neuroretinal rim thickness, quantified as minimum rim width (BMO-
MRW), is a sensitive measure for assessing early glaucomatous disease. The BMO-MRW is …