The abnormal assembly of tau protein in neurons is a pathological hallmark of multiple
neurodegenerative diseases, including Alzheimer's disease (AD). Assembled tau associates …

The endoplasmic reticulum (ER) forms a dynamic network that contacts other cellular
membranes to regulate stress responses, calcium signalling and lipid transfer. Here, using …

Serial focussed ion beam scanning electron microscopy (FIB/SEM) enables imaging and
assessment of subcellular structures on the mesoscale (10 nm to 10 µm). When applied to …

Colorectal cancer exhibits dynamic cellular and genetic heterogeneity during progression
from precursor lesions toward malignancy. Analysis of spatial multi-omic data from 31 …

Abstract/outline The field of high content imaging has steadily evolved and expanded
substantially across many industry and academic research institutions since it was first …

Fluorescence microscopy is a fundamental tool in the life sciences, but the availability of
sophisticated equipment required to yield high-quality, quantitative data is a major …

Elucidating organismal developmental processes requires a comprehensive understanding
of cellular lineages in the spatial, temporal, and molecular domains. In this study, we …

Commercial super-resolution (SR) imaging systems require a high budget, while current
more affordable open source microscopy systems lack modularity and sometimes are too …

This paper introduces OpenFIBSEM, a universal API to control Focused Ion Beam Scanning
Electron Microscopes (FIBSEM). OpenFIBSEM aims to improve the programmability and …

Motivation Particle tracking is an important step of analysis in a variety of scientific fields and
is particularly indispensable for the construction of cellular lineages from live images …