The good, the bad, and the ugly–controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy

S Callaghan, MO Senge - Photochemical & photobiological sciences, 2018 - pubs.rsc.org
Singlet oxygen, although integral to photodynamic therapy, is notoriously uncontrollable,
suffers from poor selectivity and has fast decomposition rates in biological media. Across the …

Reactive oxygen species mediated activation of a dormant singlet oxygen photosensitizer: from autocatalytic singlet oxygen amplification to chemicontrolled …

AM Durantini, LE Greene, R Lincoln… - Journal of the …, 2016 - ACS Publications
Here we show the design, preparation, and characterization of a dormant singlet oxygen
(1O2) photosensitizer that is activated upon its reaction with reactive oxygen species (ROS) …

Tuning the 1O2 Oxidation of a Phenol at the Air/Solid Interface of a Nanoparticle: Hydrophobic Surface Increases Oxophilicity

AM Durantini, L Lapoot, S Jabeen, G Ghosh, J Bipu… - Langmuir, 2023 - ACS Publications
Although silica surfaces have been used in organic oxidations for the production of
peroxides, studies of airborne singlet oxygen at interfaces are limited and have not found …

Synergism between airborne singlet oxygen and a trisubstituted olefin sulfonate for the inactivation of bacteria

R Choudhury, A Greer - Langmuir, 2014 - ACS Publications
The reactivity of a trisubstituted alkene surfactant (8-methylnon-7-ene-1 sulfonate, 1) to
airborne singlet oxygen in a solution containing E. coli was examined. Surfactant 1 was …

Photoactive fluoropolymer surfaces that release sensitizer drug molecules

G Ghosh, M Minnis, AA Ghogare… - The Journal of …, 2015 - ACS Publications
We describe a physical–organic study of two fluoropolymers bearing a photoreleasable
PEGylated photosensitizer that generates 1O2 (1Δg)[chlorin e6 methoxy tri (ethylene glycol) …

“Pointsource” Delivery of a Photosensitizer Drug and Singlet Oxygen: Eradication of Glioma Cells In Vitro

AA Ghogare, I Rizvi, T Hasan… - Photochemistry and …, 2014 - Wiley Online Library
We describe a pointsource sensitizer‐tipped microoptic device for the eradication of glioma
U87 cells. The device has a mesoporous fluorinated silica tip which emits singlet oxygen …

S, S‐chiral linker induced U shape with a syn‐facial sensitizer and photocleavable ethene group

G Ghosh, SJ Belh, C Chiemezie… - Photochemistry and …, 2019 - Wiley Online Library
There is a major need for light‐activated materials for the release of sensitizers and drugs.
Considering the success of chiral columns for the separation of enantiomer drugs, we …

Формирование связей CO, CS, CN и С-С на периферии макроцикла фитохлоринов при их химической модификации: основные методы и синтетические …

ДВ Белых - Российский химический журнал, 2017 - elibrary.ru
В обзоре рассмотрены основные методы формирования связей CO, CS, CN и С-С на
периферии макроцикла фитохлоринов при их химической модификации в синтезе …

Some observations on solasodine reactivity

I Jastrzebska, JW Morzycki - Steroids, 2017 - Elsevier
This article presents new transformations of solasodine–a representative steroid alkaloid
sapogenin from the Solanum family. Oxidation of N, O-diacetylated solasodine with either …

Fluorinated Photodynamic Therapy Device Tips and their Resistance to Fouling for In Vivo Sensitizer Release

AA Ghogare, JM Miller, B Mondal… - Photochemistry and …, 2016 - Wiley Online Library
We describe progress on a one‐step photodynamic therapy (PDT) technique that is simple:
device tip delivery of sensitizer, oxygen and light simultaneously. Control is essential for …