Antitumor alkaloids
M Suffness, GA Cordell - The alkaloids: chemistry and pharmacology, 1985 - Elsevier
Publisher Summary This chapter explores that an extremely wide range of natural product
structural types eliciting anticancer activity have been discovered, and their isolation has …
structural types eliciting anticancer activity have been discovered, and their isolation has …
Benzo [b] naphthyridines
AS Ivanov, NZ Tugusheva… - Russian chemical reviews, 2005 - iopscience.iop.org
Benzo[b]naphthyridines Page 1 Russian Chemical Reviews Benzo[b]naphthyridines To cite
this article: AS Ivanov et al 2005 Russ. Chem. Rev. 74 915 View the article online for updates …
this article: AS Ivanov et al 2005 Russ. Chem. Rev. 74 915 View the article online for updates …
Synthesis and cytotoxic activity of some new azapyranoxanthenone aminoderivatives
A series of novel azapyranoxanthenones, bearing structural similarity to the acridone
alkaloid acronycine have been designed and synthesized. Their in vitro cytotoxicities …
alkaloid acronycine have been designed and synthesized. Their in vitro cytotoxicities …
Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity
MT Cocco, C Congiu, V Onnis, M Morelli… - Bioorganic & medicinal …, 2004 - Elsevier
A new series of 2-arylamino-6-trifluoromethyl-3-carboxylic acid derivatives was synthesized
and assayed in vivo for their analgesic properties by means of writhing test in rats. When …
and assayed in vivo for their analgesic properties by means of writhing test in rats. When …
Claisen rearrangements in heteroaromatic systems
CJ Moody - Advances in heterocyclic chemistry, 1987 - Elsevier
Publisher Summary The Claisen rearrangement of heteroaromatic allyl ethers shows many
similarities to the rearrangement of simple benzenoid aromatic allyl ethers. Mechanistically …
similarities to the rearrangement of simple benzenoid aromatic allyl ethers. Mechanistically …
Synthesis, Antitumor Activity, and Mechanism of Action of Benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one Analogs of Acronycine
W Tian, R Yougnia, S Depauw… - Journal of Medicinal …, 2014 - ACS Publications
A series of 6-methoxy-3, 3, 14-trimethyl-3, 14-dihydro-7H-benzo [b] chromeno [6, 5-g][1, 8]
naphthyridin-7-one (4), 13-aza derivatives of benzo [b] acronycine, the isomeric 5-methoxy …
naphthyridin-7-one (4), 13-aza derivatives of benzo [b] acronycine, the isomeric 5-methoxy …
[图书][B] Acronycine-type alkaloids: chemistry and biology
F Tillequin, S Michel, AL Skaltsounis - 1998 - books.google.com
Acronycine (3, 12-dihydro-6-methoxy-3, 3, 12-trimethyl-7H-pyrano (2, 3-c] acridin-7-one)(1)
is a natural alkaloid which was first isolated in 1948 by the group of Hughes and Lahey [1] …
is a natural alkaloid which was first isolated in 1948 by the group of Hughes and Lahey [1] …
Efficient Synthesis of Chromeno[4,3,2‐de] [1,6]naphthyridine Derivatives via Pseudo Four‐Component Reaction
J Gan, N Luo, C Wu, X Wan, C Wang - ChemistrySelect, 2021 - Wiley Online Library
A novel approach to the synthesis of substituted 5‐amino‐4‐cyanochromeno [4, 3, 2‐de][1,
6] naphthyridine‐1‐carboxylates from a wide range of substituted 2‐hydroxybenzaldehydes …
6] naphthyridine‐1‐carboxylates from a wide range of substituted 2‐hydroxybenzaldehydes …
Formylnitroenamines: useful building blocks for nitrated pyridones and aminopyridines with functional groups
Y Nakaike, D Hayashi, N Nishiwaki, Y Tobe… - Organic & Biomolecular …, 2009 - pubs.rsc.org
β-Formyl-β-nitroenamines 1 possess both an electrophilic formyl group and a nucleophilic
amino group and, therefore, serve as C3N1 building blocks having a nitro group to afford …
amino group and, therefore, serve as C3N1 building blocks having a nitro group to afford …
Structure-activity relationships in the acronycine series
S Michel, E Seguin, F Tillequin - Current medicinal chemistry, 2002 - ingentaconnect.com
Acronycine is active against a broad spectrum of solid tumors. Structure activity relationships
demonstrated the crucial role of the 1, 2-double bond. A hypothesis of bioactivation into 1, 2 …
demonstrated the crucial role of the 1, 2-double bond. A hypothesis of bioactivation into 1, 2 …