Modular microfluidics for life sciences

J Wu, H Fang, J Zhang, S Yan - Journal of Nanobiotechnology, 2023 - Springer
The advancement of microfluidics has enabled numerous discoveries and technologies in
life sciences. However, due to the lack of industry standards and configurability, the design …

Microfluidic-based technologies for diagnosis, prevention, and treatment of COVID-19: recent advances and future directions

EA Tarim, M Anil Inevi, I Ozkan, S Kecili, E Bilgi… - Biomedical …, 2023 - Springer
The COVID-19 pandemic has posed significant challenges to existing healthcare systems
around the world. The urgent need for the development of diagnostic and therapeutic …

Biporous silica nanostructure-induced nanovortex in microfluidics for nucleic acid enrichment, isolation, and PCR-free detection

E Jeon, B Koo, S Kim, J Kim, Y Yu, H Jang… - Nature …, 2024 - nature.com
Efficient pathogen enrichment and nucleic acid isolation are critical for accurate and
sensitive diagnosis of infectious diseases, especially those with low pathogen levels. Our …

C-MEMS-derived glassy carbon electrochemical biosensors for rapid detection of SARS-CoV-2 spike protein

N Mandal, R Mitra, B Pramanick - Microsystems & Nanoengineering, 2023 - nature.com
Abstract According to a World Health Organization (WHO) report, the world has experienced
more than 766 million cases of positive SARS-CoV-2 infection and more than 6.9 million …

Nucleic Acid Amplification‐Based Technologies (NAAT)—Toward Accessible, Autonomous, and Mobile Diagnostics

V Narasimhan, H Kim, SH Lee, H Kang… - Advanced Materials …, 2023 - Wiley Online Library
The ongoing pandemic and increasing frequency of infectious disease outbreaks due to
climate change, urbanization, and global human migration have put great focus on nucleic …

Customizable Nichrome Wire Heaters for Molecular Diagnostic Applications

J Lim, W Han, LTH Thang, YW Lee, JH Shin - Biosensors, 2024 - mdpi.com
Accurate sample heating is vital for nucleic acid extraction and amplification, requiring a
sophisticated thermal cycling process in nucleic acid detection. Traditional molecular …

Portable rotary PCR system for real-time detection of Pseudomonas aeruginosa in milk

W Song, C Zhang, H Lin, T Zhang, H Liu, X Huang - Lab on a Chip, 2023 - pubs.rsc.org
The rapid quantitative detection of Pseudomonas aeruginosa in milk is of great significance
to food safety. Quantitative real-time polymerase chain reaction (qPCR) technology is a …

Multiplexed CRISPR-based methods for pathogen nucleic acid detection

CH Lamb, B Kang, C Myhrvold - Current Opinion in Biomedical Engineering, 2023 - Elsevier
Bacterial and viral pathogens are devastating to human health and well-being. In many
regions, dozens of pathogen species and variants co-circulate. Thus, it is important to detect …

RNA extraction-free reduced graphene oxide-based RT-LAMP fluorescence assay for highly sensitive SARS-CoV-2 detection

Y Zhao, J Qiu, P Jiang, M Wang, M Sun, G Fan, N Yang… - Talanta, 2024 - Elsevier
Infectious diseases have always been a seriously endanger for human life and health. A
rapid, accurate and ultra-sensitive virus nucleic acid detection is still a challenge to deal with …

Quantitative and dynamic profiling of human gut core microbiota by real-time PCR

Z Yan, T Hao, Y Yan, Y Zhao, Y Wu, Y Tan, Y Bi… - Applied Microbiology …, 2024 - Springer
The human gut microbiota refers to a diverse community of microorganisms that
symbiotically exist in the human intestinal system. Altered microbial communities have been …