Simple Summary Castration-resistant prostate cancer (CRPC) is an advanced form of
prostate cancer with a low survival rate, as the CRPC patients only survive for 9–13 months …

Hedgehog (Hh) signaling is an essential growth factor signaling pathway especially in the
regulation of epithelial–mesenchymal interactions (EMI) during the development of the …

Epithelial cells orchestrate a series of intercellular signaling events in response to tissue
damage. While the epididymis is composed of a pseudostratified epithelium that controls the …

Prostate development and regeneration depend on prostate stem cell function, the delicate
balance of stem cell self-renewal and differentiation. However, mechanisms modulating …

Activation of epithelial-AR signaling is identified as the major cause of hyperproliferation of
the cells during benign and malignant prostate conditions. However, the contribution of …

Résumé La voie de signalisation Hedgehog est impliquée dans de nombreux processus
nécessaires au bon développement et maintien des organes. Elle a lieu par fixation de ses …

Abstract Benign Prostate Hyperplasia (BPH) and Prostate cancer (PCa) share some traits
like androgen-dependent growth, disease symptoms, and response to anti-androgen …

Stromal-epithelial interaction is essential for maintaining the niche of stem cells and
regulating organ development and cancer progression. Numerous cell signaling pathways …