Autophagy genes in biology and disease
H Yamamoto, S Zhang, N Mizushima - Nature Reviews Genetics, 2023 - nature.com
Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …
Fluorescent Flippers: Small‐Molecule Probes to Image Membrane Tension in Living Systems
XX Chen, F Bayard, N Gonzalez‐Sanchis… - Angewandte …, 2023 - Wiley Online Library
Flipper probes have been introduced as small molecule fluorophores to image physical
forces, that is, membrane tension in living systems. Their emergence over one decade is …
forces, that is, membrane tension in living systems. Their emergence over one decade is …
The autophagy protein ATG9A enables lipid mobilization from lipid droplets
E Mailler, CM Guardia, X Bai, M Jarnik… - Nature …, 2021 - nature.com
The multispanning membrane protein ATG9A is a scramblase that flips phospholipids
between the two membrane leaflets, thus contributing to the expansion of the phagophore …
between the two membrane leaflets, thus contributing to the expansion of the phagophore …
[HTML][HTML] ATG9 vesicles comprise the seed membrane of mammalian autophagosomes
As the autophagosome forms, its membrane surface area expands rapidly, while its volume
is kept low. Protein-mediated transfer of lipids from another organelle to the autophagosome …
is kept low. Protein-mediated transfer of lipids from another organelle to the autophagosome …
[HTML][HTML] Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes
The biogenesis of mammalian autophagosomes remains to be fully defined. Here, we used
cellular and in vitro membrane fusion analyses to show that autophagosomes are formed …
cellular and in vitro membrane fusion analyses to show that autophagosomes are formed …
ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion
ATG5 is a part of the E3 ligase directing lipidation of ATG8 proteins, a process central to
membrane atg8ylation and canonical autophagy. Loss of Atg5 in myeloid cells causes early …
membrane atg8ylation and canonical autophagy. Loss of Atg5 in myeloid cells causes early …
[HTML][HTML] Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage
We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG)
formation and that the process termed membrane atg8ylation coordinates SG formation with …
formation and that the process termed membrane atg8ylation coordinates SG formation with …
A possible role for VPS13-family proteins in bulk lipid transfer, membrane expansion and organelle biogenesis
TJ Melia, KM Reinisch - Journal of cell science, 2022 - journals.biologists.com
At organelle–organelle contact sites, proteins have long been known to facilitate the rapid
movement of lipids. Classically, this lipid transport involves the extraction of single lipids into …
movement of lipids. Classically, this lipid transport involves the extraction of single lipids into …
Autophagy in muscle regeneration: potential therapies for myopathies
W Chen, Y Chen, Y Liu, X Wang - Journal of Cachexia …, 2022 - Wiley Online Library
Autophagy classically functions as a physiological process to degrade cytoplasmic
components, protein aggregates, and/or organelles, as a mechanism for nutrient …
components, protein aggregates, and/or organelles, as a mechanism for nutrient …
Mechanoregulatory Cholesterol Oxidase‐Functionalized Nanoscale Metal–Organic Framework Stimulates Pyroptosis and Reinvigorates T Cells
Cancer cells alter mechanical tension in their cell membranes. New interventions to regulate
cell membrane tension present a potential strategy for cancer therapy. Herein, the increase …
cell membrane tension present a potential strategy for cancer therapy. Herein, the increase …