Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …

Flipper probes have been introduced as small molecule fluorophores to image physical
forces, that is, membrane tension in living systems. Their emergence over one decade is …

The multispanning membrane protein ATG9A is a scramblase that flips phospholipids
between the two membrane leaflets, thus contributing to the expansion of the phagophore …

As the autophagosome forms, its membrane surface area expands rapidly, while its volume
is kept low. Protein-mediated transfer of lipids from another organelle to the autophagosome …

The biogenesis of mammalian autophagosomes remains to be fully defined. Here, we used
cellular and in vitro membrane fusion analyses to show that autophagosomes are formed …

ATG5 is a part of the E3 ligase directing lipidation of ATG8 proteins, a process central to
membrane atg8ylation and canonical autophagy. Loss of Atg5 in myeloid cells causes early …

We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG)
formation and that the process termed membrane atg8ylation coordinates SG formation with …

At organelle–organelle contact sites, proteins have long been known to facilitate the rapid
movement of lipids. Classically, this lipid transport involves the extraction of single lipids into …

Autophagy classically functions as a physiological process to degrade cytoplasmic
components, protein aggregates, and/or organelles, as a mechanism for nutrient …

Cancer cells alter mechanical tension in their cell membranes. New interventions to regulate
cell membrane tension present a potential strategy for cancer therapy. Herein, the increase …