It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …

One of the most unique physical features of cell adhesion to external surfaces is the active
generation of mechanical force at the cell-material interface. This includes pulling forces …

How cells respond to physical cues in order to meet and withstand the physical demands of
their immediate surroundings has been of great interest for many years, with current …

Abnormalities in nuclear and chromatin organization are hallmarks of many diseases
including cancer. In this review, we highlight our understanding of how the cellular …

Extracellular matrix signals from the microenvironment regulate gene expression patterns
and cell behavior. Using a combination of experiments and geometric models, we …

Cells contain several mechanosensing components that transduce mechanical signals into
biochemical cascades. During cell–ECM adhesion, a complex network of molecules …

Chromosomes within eukaryotic cell nuclei at interphase are not positioned at random, since
gene-rich chromosomes are predominantly found towards the interior of the cell nucleus …

An introduction to the physical properties of living active matter at the mesoscopic scale
(tens of nanometers to micrometers) and their unique features compared with “dead,” …

Chromosome territories (CTs) in higher eukaryotes occupy tissue-specific non-random three-
dimensional positions in the interphase nucleus. To understand the mechanisms underlying …

Tissue engineers use biomaterials or apply forces to alter cell behaviors and cure
damaged/diseased tissues. The external physical cues perceived by cells are transduced …