Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …

Depression occurs in around 35% of patients with Parkinson disease (PD) and is often
persistent. Symptoms of depression can be evident in individuals at the time of diagnosis …

Parkinson's disease is a chronic neurodegenerative disorder characterized by the motor
symptoms of bradykinesia, tremor, rigidity and postural instability. However, non-motor …

Neurotransmitters, as important chemical small molecules, perform the function of neural
signal transmission from cell to cell. Excess concentrations of neurotransmitters are often …

The SLC6 family of secondary active transporters are integral membrane solute carrier
proteins characterized by the Na+-dependent translocation of small amino acid or amino …

The paper reviews of all of the current evidence on Theory of Mind (ToM) abilities in patients
with neurodegenerative diseases. ToM refers to the abilities to attribute mental states to …

Parkinson's disease (PD) is the second most common neurodegenerative disorder mostly
affecting the aging population over sixty. Cardinal symptoms including, tremors, muscle …

Post-mortem and neuroimaging studies suggest that the serotonergic system, which
originates from the brainstem raphe nuclei, is disrupted in Parkinson's disease. This could …

For several decades, the dopamine precursor levodopa has been the primary therapy for
Parkinson's disease (PD). However, not all of the motor and non-motor features of PD can …

Interest in serotonergic involvement in Parkinson's disease (PD) has focussed recently on
the possibility that the remaining serotonin neurons innervating striatum (caudate and …