Entropy-enthalpy compensation: role and ramifications in biomolecular ligand recognition and design

JD Chodera, DL Mobley - Annual review of biophysics, 2013 - annualreviews.org
Recent calorimetric studies of interactions between small molecules and biomolecular
targets have generated renewed interest in the phenomenon of entropy-enthalpy …

[HTML][HTML] Thermophoresis of biological and biocompatible compounds in aqueous solution

D Niether, S Wiegand - Journal of Physics: Condensed Matter, 2019 - iopscience.iop.org
With rising popularity of microscale thermophoresis for the characterisation of protein-ligand
binding reactions and possible applications in microfluidic devices, there is a growing …

High-resolution structures with bound Mn2+ and Cd2+ map the metal import pathway in an Nramp transporter

S Ray, SP Berry, EA Wilson, CH Zhang, M Shekhar… - Elife, 2023 - elifesciences.org
Abstract Transporters of the Nramp (Natural resistance-associated macrophage protein)
family import divalent transition metal ions into cells of most organisms. By supporting metal …

Enthalpy–entropy compensation (EEC) effect: decisive role of free energy

A Pan, T Kar, AK Rakshit, SP Moulik - The Journal of Physical …, 2016 - ACS Publications
The “enthalpy–entropy compensation”(EEC) effect has been a long-standing fascinating yet
unresolved phenomenon in chemical thermodynamics. The reasons for the observation of …

Insights into protein-curcumin interactions: Kinetics and thermodynamics of curcumin and lactoferrin binding

CA Lelis, NM Nunes, HMC de Paula, YL Coelho… - Food …, 2020 - Elsevier
The thermodynamics of curcumin (CUR) binding with bovine lactoferrin (bLF) was
investigated by employing fluorescence spectroscopy (FS) and surface plasmon resonance …

An unrevealed molecular function of corannulene Buckybowl glycoconjugates in selective tumor annihilation by targeting the cancer‐specific Warburg effect

S Liu, Z Sun, M Liang, W Song, R Zhang… - Advanced …, 2022 - Wiley Online Library
The biomedical application of corannulene π‐bowls is historically limited by low solubility
and bioavailability despite the potential in their unique electronic properties for new …

On the role of alginate structure in complexing with lysozyme and application for enzyme delivery

JP Fuenzalida, PK Nareddy, I Moreno-Villoslada… - Food …, 2016 - Elsevier
This study addresses the physicochemical properties and potential application of colloidal
stable particles prepared by electrostatic self-assembly of alginate (Alg) and lysozyme (Lyz) …

The enthalpy-entropy compensation phenomenon. Limitations for the use of some basic thermodynamic equations

S Khrapunov - Current Protein and Peptide Science, 2018 - ingentaconnect.com
The thermodynamic analyses of proteins, protein-ligands and protein-nucleic acid
complexes involves the entropy–enthalpy (SH) compensation phenomenon. We have …

Molecular rigidity and enthalpy–entropy compensation in DNA melting

F Vargas-Lara, FW Starr, JF Douglas - Soft Matter, 2017 - pubs.rsc.org
Enthalpy–entropy compensation (EEC) is observed in diverse molecular binding processes
of importance to living systems and manufacturing applications, but this widely occurring …

[HTML][HTML] Solvent effects on ligand binding to a serine protease

SM Gopal, F Klumpers, C Herrmann… - Physical Chemistry …, 2017 - pubs.rsc.org
Solvation plays an important role in virtually all biomolecular recognition and binding
processes. However, the consequences of changes in solvation conditions often remain …