[HTML][HTML] Junctions in DNA: underexplored targets for therapeutic intervention
E Ivens, MMD Cominetti, M Searcey - Bioorganic & Medicinal Chemistry, 2022 - Elsevier
DNA has been a key target for cancer therapy, with a range of compounds able to bind and
either impair its processing or induce damage. Targeting DNA with small molecules in a truly …
either impair its processing or induce damage. Targeting DNA with small molecules in a truly …
Bacterial persister cells and development of antibiotic resistance in chronic infections: an update
AP Kunnath, M Suodha Suoodh… - British Journal of …, 2024 - frontierspartnerships.org
The global issue of antimicrobial resistance poses significant challenges to public health.
The World Health Organization (WHO) has highlighted it as a major global health threat …
The World Health Organization (WHO) has highlighted it as a major global health threat …
DNA Repair in Staphylococcus aureus
KP Ha, AM Edwards - Microbiology and Molecular Biology …, 2021 - Am Soc Microbiol
Staphylococcus aureus is a common cause of both superficial and invasive infections of
humans and animals. Despite a potent host response and apparently appropriate antibiotic …
humans and animals. Despite a potent host response and apparently appropriate antibiotic …
Role of DNA Double-Strand Break Formation in Gyrase Inhibitor-Mediated Killing of Nonreplicating Persistent Mycobacterium tuberculosis in Caseum
P Ashwath, P Osiecki, D Weiner, LE Via… - ACS Infectious …, 2024 - ACS Publications
Tuberculosis is the leading cause of mortality by infectious agents worldwide. The necrotic
debris, known as caseum, which accumulates in the center of pulmonary lesions and …
debris, known as caseum, which accumulates in the center of pulmonary lesions and …
[HTML][HTML] DeepFoci: deep learning-based algorithm for fast automatic analysis of DNA double-strand break ionizing radiation-induced foci
DNA double-strand breaks (DSBs), marked by ionizing radiation-induced (repair) foci
(IRIFs), are the most serious DNA lesions and are dangerous to human health. IRIF …
(IRIFs), are the most serious DNA lesions and are dangerous to human health. IRIF …
[HTML][HTML] Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles as Natural Nanocarriers in the Treatment of Nephrotoxic Injury In Vitro
Umbilical cord mesenchymal stem cell-derived extracellular vesicles (UC-EVs) are valuable
in nanomedicine as natural nanocarriers, carrying information molecules from their parent …
in nanomedicine as natural nanocarriers, carrying information molecules from their parent …
CS-cells: a CRISPR-Cas12 DNA device to generate chromosome-shredded cells for efficient and safe molecular biomanufacturing
Synthetic biology holds great promise for translating ideas into products to address the
grand challenges facing humanity. Molecular biomanufacturing is an emerging technology …
grand challenges facing humanity. Molecular biomanufacturing is an emerging technology …
Codeine dysregulates ribosome biogenesis in Escherichia coli with DNA double-strand breaks to chart path to new classes of antibiotics
V Amarh, BA Abbey, SA Acheampong… - Future Drug …, 2023 - Taylor & Francis
Aim: A bacterial genetics-guided approach was utilized for the discovery of new compounds
affecting bacterial genome stability. Materials & methods: Fungal extracts and fractions were …
affecting bacterial genome stability. Materials & methods: Fungal extracts and fractions were …
Obstacles to DNA replication in Escherichia coli and the role of UvrD helicase in their resolution
DW Warecka - 2024 - etheses.whiterose.ac.uk
UvrD is a multi-functional Escherichia coli helicase. It is widely involved in DNA repair,
including its DNA unwinding role during mismatch repair and RNAP removal role during …
including its DNA unwinding role during mismatch repair and RNAP removal role during …
[HTML][HTML] Оценка биобезопасности наноструктурных минералов, разработанных для применения в качестве удобрений
ИА Дегтярева, ЭВ Бабынин… - … . Прикладная химия и …, 2022 - cyberleninka.ru
Природные цеолиты эффективно используются в качестве удобрений, субстратов и
носителей для пестицидов, а также сорбентов при восстановлении загрязненных почв …
носителей для пестицидов, а также сорбентов при восстановлении загрязненных почв …