Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory
Phenotypic plasticity, or adaptability, of a cell determines its ability to survive and function
within changing cellular environments. Changes in the mechanical environment, ranging …
within changing cellular environments. Changes in the mechanical environment, ranging …
Nuclear envelope mechanobiology: linking the nuclear structure and function
The nucleus, central to cellular activity, relies on both direct mechanical input as well as its
molecular transducers to sense external stimuli and respond by regulating intra-nuclear …
molecular transducers to sense external stimuli and respond by regulating intra-nuclear …
Nuclear mechanics within intact cells is regulated by cytoskeletal network and internal nanostructures
The mechanical properties of the cellular nucleus are extensively studied as they play a
critical role in important processes, such as cell migration, gene transcription, and stem cell …
critical role in important processes, such as cell migration, gene transcription, and stem cell …
[HTML][HTML] Deformation microscopy for dynamic intracellular and intranuclear mapping of mechanics with high spatiotemporal resolution
S Ghosh, B Seelbinder, JT Henderson, RD Watts… - Cell reports, 2019 - cell.com
Structural heterogeneity is a hallmark of living cells that drives local mechanical properties
and dynamic cellular responses. However, the robust quantification of intracellular …
and dynamic cellular responses. However, the robust quantification of intracellular …
Dedifferentiation alters chondrocyte nuclear mechanics during in vitro culture and expansion
The biophysical features of a cell can provide global insights into diverse molecular
changes, especially in processes like the dedifferentiation of chondrocytes. Key biophysical …
changes, especially in processes like the dedifferentiation of chondrocytes. Key biophysical …
Image‐based elastography of heterochromatin and euchromatin domains in the deforming cell nucleus
Chromatin of the eukaryotic cell nucleus comprises microscopically dense heterochromatin
and loose euchromatin domains, each with distinct transcriptional ability and roles in cellular …
and loose euchromatin domains, each with distinct transcriptional ability and roles in cellular …
A Hierarchical Mechanotransduction System: From Macro to Micro
R Cao, H Tian, Y Tian, X Fu - Advanced Science, 2024 - Wiley Online Library
Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including
mechanical forces and properties, are sensed and translated into biochemical signals …
mechanical forces and properties, are sensed and translated into biochemical signals …
[PDF][PDF] Active muscular hydraulics
S Shankar, L Mahadevan - bioRxiv, 2022 - scholar.archive.org
What limits the rate of contraction in muscle? The molecular cycling of actomyosin
crossbridges has typically been assumed to be rate limiting, but muscle is a soft, wet and …
crossbridges has typically been assumed to be rate limiting, but muscle is a soft, wet and …
Integrated multiscale biomaterials experiment and modeling
GM Genin, VB Shenoy, GCY Peng… - … biomaterials science & …, 2017 - ACS Publications
The use of metals in structural engineering underwent a transformation in the 20th century,
in which empirical design laws were replaced by mathematical models that arose from …
in which empirical design laws were replaced by mathematical models that arose from …
Active hydraulics and odd elasticity of muscle fibers
S Shankar, L Mahadevan - bioRxiv, 2022 - biorxiv.org
What limits the rate of contraction in muscle? The molecular cycling of actomyosin
crossbridges has typically been assumed to be rate limiting, but muscle is a soft, wet and …
crossbridges has typically been assumed to be rate limiting, but muscle is a soft, wet and …