Despite the pre-eminence of the mouse in modelling human disease, several aspects of
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …

Arguably, the main challenge for contemporary genetics is to understand the function of
every gene in a mammalian genome. The mouse has emerged as a model for this task …

We genotyped 2,861 cases of primary biliary cirrhosis (PBC) from the UK PBC Consortium
and 8,514 UK population controls across 196,524 variants within 186 known autoimmune …

Accumulation of DNA damage leading to adult stem cell exhaustion has been proposed to
be a principal mechanism of ageing. Here we address this question by taking advantage of …

Human FTO gene variants are associated with body mass index and type 2 diabetes.
Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO …

Glucagon, secreted from pancreatic islet α cells, stimulates gluconeogenesis and liver
glycogen breakdown. The mechanism regulating glucagon release is debated, and …

Loss of a whole chromosome 5 or a deletion of the long arm, del (5q), is a recurring
abnormality in myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML). To …

Thrombotic complications of vascular disease are the leading cause of morbidity and
mortality in most industrialized countries. Despite this, safe and effective drugs targeting …

Objective The rat is one of the most important model organisms for biomedical and
pharmacological research. However, the generation of novel models for studying specific …

Mutations in a number of genes have been linked to inherited dilated cardiomyopathy
(DCM). However, such mutations account for only a small proportion of the clinical cases …