Mesenchymal stem cells (MSCs), coming from a wide range of sources, have multi-
directional differentiation ability. MSCs play vital roles in immunomodulation, hematopoiesis …

Pyroptosis is a recently described mechanism of programmed cell death mediated by
proteins of the gasdermin family. Widely recognized signaling cascades include the …

Intervertebral disc (IVD) degeneration (IDD), a highly prevalent pathological condition
worldwide, is widely associated with back pain. Treatments available compensate for the …

Low back pain (LBP) is a common and important clinical problem. In addition to pain,
patients are also affected by personal, social, and economic burdens. Intervertebral disc …

Intervertebral disc degeneration (IVDD) is one of the leading causes of lower back pain.
Although IVDD cannot directly cause death, it can cause pain, psychological burdens, and …

Hydrogels are widely used to explore emerging minimally invasive strategies for
intervertebral disc degeneration (IVDD) due to their suitability as drug and cell delivery …

Intervertebral disc degeneration arises from damage or degeneration of the nucleus
pulposus (NP). In this study, we developed a photo-crosslinkable hydrogel incorporating …

As a major cause of low back pain, intervertebral disc degeneration is an increasingly
prevalent chronic disease worldwide that leads to huge annual financial losses. The …

Degenerative disc disease (DDD) is a pervasive condition that limits quality of life and
burdens economies worldwide. Conventional pharmacological treatments primarily aimed at …

Introduction Discogenic low back pain (DLBP) is a common disease, and its occurrence is
closely related to intervertebral disc (IVD) degeneration. At present, none of the traditional …