Several viruses are involved in the development of systemic vasculitides. Hepatitis C virus
(HCV) has been shown to be closely related to mixed cryoglobulinaemia, an immune …

The pathogenesis of autoantibody-mediated cellular and tissue lesions in autoimmune
diseases is most straightforwardly attributable to the combined action of self-antigen binding …

Abstract Treatment of hepatitis C (HCV)–mixed cryoglobulinemia (MC) may target either the
viral trigger (HCV) or the downstream B-cell clonal expansion. Prospective cohort study of …

Understanding the contribution of complement activation and innate immunity to the
evolution of membranoproliferative glomerulonephritis promises to provide new therapeutic …

Cryoglobulins are immunoglobulins that reversibly precipitate in the cold. They come in
different flavours and, as such, are differentially associated with lymphoproliferative …

Objective Lupus‐prone BXSB mice develop monocytosis characterized by selective
accumulation of the Gr‐1–monocyte subset. The aim of this study was to explore the …

Hepatitis C virus (HCV) infection causes hepatic and extrahepatic organ involvement.
Chronic kidney disease (CKD) is a prevalent non-communicable disorder, accounting for …

Many forms of glomerulonephritis are triggered by Ab localization in the glomerulus, but the
mechanisms by which this induces glomerular inflammation are not fully understood. In this …

Abstract Monoclonal 6-19 IgG3 anti-IgG2a rheumatoid factor derived from lupus-prone MRL-
Fas lpr mice can induce GN and cryoglobulinemia, but the features that confer nephritogenic …

As vasculitis can affect blood vessels of all sizes, it is within disease subsets that there are
predilections for certain vessel sizes and/or vessel location. Ultimately, the predilection for …