Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …

Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

Iron is an essential trace metal for almost all organisms, including human; however,
oxidative stress can easily be caused when iron is in excess, producing toxicity to the human …

Brain iron accumulation has been found to accelerate disease progression in amyloid-β (Aβ)
positive Alzheimer patients, though the mechanism is still unknown. Microglia have been …

Carbon dots (CDs) have been widely used in recent years because of their excellent water
solubility and abundant surface functional groups. However, compared with quantum dots or …

Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Background Ferroptosis, as a new form of cell death, is different from other cell deaths such
as autophagy or senescence. Ferroptosis involves in the pathophysiological progress of …

Objective This paper is a proposal for an update of the iron hypothesis of Alzheimer's
disease (AD), based on large‐scale emerging evidence. Background Iron featured …

Microtubule-associated protein tau is characterized by the fact that it is an intrinsically
disordered protein due to its lack of a stable conformation and high flexibility. Intracellular …

Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring
when there is an imbalance of redox homeostasis in the cell. Nuclear factor erythroid 2 …