Prebiotic peptides: Molecular hubs in the origin of life
The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …
Hierarchical materials from high information content macromolecular building blocks: construction, dynamic interventions, and prediction
Hierarchical materials that exhibit order over multiple length scales are ubiquitous in nature.
Because hierarchy gives rise to unique properties and functions, many have sought …
Because hierarchy gives rise to unique properties and functions, many have sought …
Alpha-synuclein aggregation pathway in Parkinson's disease: current status and novel therapeutic approaches
M Vidović, MG Rikalovic - Cells, 2022 - mdpi.com
Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …
Mechanistic insight into the design of chemical tools to control multiple pathogenic features in Alzheimer's disease
Conspectus Alzheimer's disease (AD) is the most common form of dementia and is
characterized by memory loss and cognitive decline. Approximately 50 million people …
characterized by memory loss and cognitive decline. Approximately 50 million people …
Signaling by LncRNAs: Structure, cellular homeostasis, and disease pathology
The cellular signaling network involves co-ordinated regulation of numerous signaling
molecules that aid the maintenance of cellular as well as organismal homeostasis. Aberrant …
molecules that aid the maintenance of cellular as well as organismal homeostasis. Aberrant …
Nitrogen‐doped carbonized polymer dots: a potent scavenger and detector targeting Alzheimer's β‐amyloid plaques
W Gao, W Wang, X Dong, Y Sun - Small, 2020 - Wiley Online Library
The fibrillization and deposition of β‐amyloid protein (Aβ) are recognized to be the
pathological hallmarks of Alzheimer's disease (AD), which signify the need for the effective …
pathological hallmarks of Alzheimer's disease (AD), which signify the need for the effective …
Epigallocatechin gallate-derived carbonized polymer dots: A multifunctional scavenger targeting Alzheimer's β-amyloid plaques
X Lin, W Liu, X Dong, Y Sun - Acta Biomaterialia, 2023 - Elsevier
The design of high-efficiency scavengers targeting β-amyloid protein (Aβ) plaques in the
progress of Alzheimer's disease (AD) has been recognized as an effective way to prevent …
progress of Alzheimer's disease (AD) has been recognized as an effective way to prevent …
Current strategies of detecting Aβ species and inhibiting Aβ aggregation: Status and prospects
J Li, W Liao, D Huang, M Ou, T Chen, X Wang… - Coordination Chemistry …, 2023 - Elsevier
Alzheimer's disease (AD) is a central neurodegenerative disorder characterized by
behavioral disturbance and progressive cognitive impairment, and it is common in pre …
behavioral disturbance and progressive cognitive impairment, and it is common in pre …
Occurrence of morpholine in central nervous system drug discovery
E Lenci, L Calugi, A Trabocchi - ACS Chemical Neuroscience, 2021 - ACS Publications
Developing drugs for the central nervous system (CNS) requires fine chemical modifications,
as a strict balance between size and lipophilicity is necessary to improve the permeability …
as a strict balance between size and lipophilicity is necessary to improve the permeability …
Photoresponsive materials for intensified modulation of Alzheimer's amyloid-β protein aggregation: a review
W Liu, X Dong, Y Liu, Y Sun - Acta Biomaterialia, 2021 - Elsevier
The abnormal self-assembly of amyloid-β protein (Aβ) into toxic aggregates is a major
pathological hallmark of Alzheimer's disease (AD). Modulation of Aβ fibrillization with …
pathological hallmark of Alzheimer's disease (AD). Modulation of Aβ fibrillization with …