Deleterious mutations decrease reproductive fitness and are ubiquitous in genomes. Given
that many organisms face ongoing threats of extinction, there is interest in elucidating the …

Our ability to assess the threat posed by the genetic load to small and declining populations
has been greatly improved by advances in genome sequencing and computational …

Understanding the factors that cause endangered populations to either grow or decline is
crucial for preserving biodiversity. Conservation efforts often address extrinsic threats, such …

Species persistence can be influenced by the amount, type, and distribution of diversity
across the genome, suggesting a potential relationship between historical demography and …

As of 2022, the International Union for Conservation of Nature (IUCN) Red List estimates
that more than 32% of fungal, plant, and animal species are threatened with extinction. This …

Linking genetic diversity to extinction is a common goal in genomic studies. Recently, a
debate has arisen regarding the importance of genetic variation in conservation as some …

Twentieth century industrial whaling pushed several species to the brink of extinction, with
fin whales being the most impacted. However, a small, resident population in the Gulf of …

When new mutations arise at functional sites they are more likely to impair than improve
fitness. If not removed by purifying selection, such deleterious mutations will generate a …

Deleterious genetic variation is abundant in wild populations, and understanding the
ecological and conservation implications of such variation is an area of active research …

A key action of the new Global Biodiversity Framework is the maintenance of genetic
diversity in all species to safeguard their adaptive potential. To achieve this goal, a …