Designing biological circuits: from principles to applications

D Chakraborty, R Rengaswamy… - ACS Synthetic Biology, 2022 - ACS Publications
Genetic circuit design is a well-studied problem in synthetic biology. Ever since the first
genetic circuits─ the repressilator and the toggle switch─ were designed and implemented …

[HTML][HTML] Trumpet is an operating system for simple and robust cell-free biocomputing

JA Sharon, C Dasrath, A Fujiwara, A Snyder… - Nature …, 2023 - nature.com
Biological computation is becoming a viable and fast-growing alternative to traditional
electronic computing. Here we present a biocomputing technology called Trumpet …

Distributed computing with engineered bacteria and its application in solving chemically generated 2× 2 maze problems

K Sarkar, S Chakraborty, D Bonnerjee… - ACS Synthetic …, 2021 - ACS Publications
This work presented an application of genetic distributed computing, where an abstract
computational problem was mapped on a complex truth table and solved using simple …

A logically reversible double Feynman gate with molecular engineered bacteria arranged in an artificial neural network-type architecture

R Srivastava, S Bagh - ACS Synthetic Biology, 2022 - ACS Publications
Reversible logic gates are the key components of reversible computing that map inputs and
outputs in a certain one-to-one pattern so that the output signals can reveal the pattern of the …

Regulation strategies for two-output biomolecular networks

E Alexis, CCM Schulte, L Cardelli… - Journal of the …, 2023 - royalsocietypublishing.org
Feedback control theory facilitates the development of self-regulating systems with desired
performance which are predictable and insensitive to disturbances. Feedback regulatory …

[HTML][HTML] Bioconjugate Chemistry: Enabling Innovation and Fostering Community at the Nexus of Synthetic and Biological Research

TM Reineke - Bioconjugate Chemistry, 2022 - ACS Publications
Bioconjugate chemistry the ligation of synthetic and biological entities integrates
important scientific and engineering fields enabling a multitude of revolutionary …

Design and analysis of genetic feedback architectures for synthetic biology

E Alexis - 2023 - ora.ox.ac.uk
Synthetic Biology seeks to design and assemble novel biological systems with favourable
properties. It allows us to comprehend and modify the fundamental mechanisms of life and …

Virtual Parts Repository 2: Model-driven design of genetic regulatory circuits

G Mısırlı, B Yang, K James, A Wipat - ACS Synthetic Biology, 2021 - ACS Publications
Engineering genetic regulatory circuits is key to the creation of biological applications that
are responsive to environmental changes. Computational models can assist in …

Synthetic Genetic Reversible Feynman Gate in a Single E. coli Cell and Its Application in Bacterial to Mammalian Cell Information Transfer

R Srivastava, K Sarkar, D Bonnerjee… - ACS Synthetic …, 2022 - ACS Publications
Reversible computing is a nonconventional form of computing where the inputs and outputs
are mapped in a unique one-to-one fashion. Reversible logic gates in single living cells …

Lego-like Mixing and Matching of Engineered Bacteria Configure Full Subtractor and Adder Through an Artificial Neural Network Type Architecture

D Bonnerjee, S Chakraborty, S Bagh - bioRxiv, 2023 - biorxiv.org
One of the long-term goals of synthetic bioengineering is to create configurable and
programmable biological systems by just mixing and matching “LEGO”-like bio-modules …