Understanding carbon catabolite repression in Escherichia coli using quantitative models
Carbon catabolite repression (CCR) controls the order in which different carbon sources are
metabolized. Although this system is one of the paradigms of the regulation of gene …
metabolized. Although this system is one of the paradigms of the regulation of gene …
Figure 1 theory meets figure 2 experiments in the study of gene expression
It is tempting to believe that we now own the genome. The ability to read and rewrite it at will
has ushered in a stunning period in the history of science. Nonetheless, there is an Achilles' …
has ushered in a stunning period in the history of science. Nonetheless, there is an Achilles' …
Glucose becomes one of the worst carbon sources for E.coli on poor nitrogen sources due to suboptimal levels of cAMP
In most conditions, glucose is the best carbon source for E. coli: it provides faster growth
than other sugars and is consumed first in sugar mixtures. Here we identify conditions in …
than other sugars and is consumed first in sugar mixtures. Here we identify conditions in …
Hierarchy of non-glucose sugars in Escherichia coli
G Aidelberg, BD Towbin, D Rothschild, E Dekel… - BMC systems …, 2014 - Springer
Background Understanding how cells make decisions, and why they make the decisions
they make, is of fundamental interest in systems biology. To address this, we study the …
they make, is of fundamental interest in systems biology. To address this, we study the …
Optimality and sub-optimality in a bacterial growth law
Organisms adjust their gene expression to improve fitness in diverse environments. But
finding the optimal expression in each environment presents a challenge. We ask how good …
finding the optimal expression in each environment presents a challenge. We ask how good …
Novel insights from hybrid LacI/GalR proteins: family-wide functional attributes and biologically significant variation in transcription repression
S Meinhardt, MW Manley Jr, NA Becker… - Nucleic acids …, 2012 - academic.oup.com
LacI/GalR transcription regulators have extensive, non-conserved interfaces between their
regulatory domains and the 18 amino acids that serve as 'linkers' to their DNA-binding …
regulatory domains and the 18 amino acids that serve as 'linkers' to their DNA-binding …
The need for integrated approaches in metabolic engineering
This review highlights state-of-the-art procedures for heterologous small-molecule
biosynthesis, the associated bottlenecks, and new strategies that have the potential to …
biosynthesis, the associated bottlenecks, and new strategies that have the potential to …
Individual-versus group-optimality in the production of secreted bacterial compounds
How unicellular organisms optimize the production of compounds is a fundamental
biological question. While it is typically thought that production is optimized at the individual …
biological question. While it is typically thought that production is optimized at the individual …
Evolutionary constraints in variable environments, from proteins to networks
Environmental changes can not only trigger a regulatory response, but also impose
evolutionary pressures that can modify the underlying regulatory network. Here, we review …
evolutionary pressures that can modify the underlying regulatory network. Here, we review …
Universality and predictability in molecular quantitative genetics
A Nourmohammad, T Held, M Lässig - Current opinion in genetics & …, 2013 - Elsevier
Molecular traits, such as gene expression levels or protein binding affinities, are increasingly
accessible to quantitative measurement by modern high-throughput techniques. Such traits …
accessible to quantitative measurement by modern high-throughput techniques. Such traits …