Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in
the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice …

Over the last 100–120 years, due to the ever-increasing importance of fluorine-containing
compounds in modern technology and daily life, the explosive development of the …

1.1. Brief Historical Overview As expected from the fluorine position on the periodic table of
elements, it possesses some extreme properties, in particular, ultimate electronegativity and …

Fluorine has emerged as a “magic element” in medicinal chemistry, crop, and materials
science. 1 Although fluorine is the most abundant halogen in the earth's crust, it is contained …

Thirteen new fluorine-containing drugs, which have been granted approval by the US Food
and Drug Administration (FDA) in 2020, are profiled in this review. Therapeutic areas of …

Which elements are essential for human life? Here we make an element-by-element journey
through the periodic table and attempt to assess whether elements are essential or not, and …

A series of 2, 4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from
triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted …

Conspectus Efforts to chemically modify nucleic acids got underway merely a decade after
the discovery of the DNA double helix and initially targeted nucleosides and nucleotides …

Trace elements exist in the environment in small amounts but play an essential part in
sustaining various physiological and metabolic processes occurring within living tissues, as …

Lack of efficacy and toxicity are considered to be major reasons for drug failures and
pharmacokinetics governs them to a large extent. Compound with favorable …